Profile of biochemical markers in cystic fibrosis. Prospective study about 13 cases

##plugins.themes.academic_pro.article.sidebar##

Published Jun 10, 2011
Download
pdf
Vol. 89 No. 6 (2011): Issue Jun 2011

##plugins.themes.academic_pro.article.main##

Raja Belhaj
Wided Souissi
Sondes Hadj frej
Amina Bibi
Taieb Messaoud

Abstract

Background: To study the disturbances of biochemical parameters which make it possible to evaluate the nutritional state during the cystic fibrosis.
Methods: Prospective study about 13 cases hospitalized over a 7 months period, whose age varies between 2 months and 12 years and adressed for a suspicion of cystic fibrosis. For all the patients we made a clinical collection of the data and a biochemical study.
Results: Hypoprotidemia (protidemia < 60 g/l) was noted in 6 cases. Three cases presented a hypocalcaemia (calcemia < 2.20 mmol/l). A hypomagnesaemia (magnesemia < 0.70 mmol/L) was observed in 2 cases. The totality of the patients presented zinc concentrations lower than the normal value. Iron concentrations lower than the normal (11- 24 mmol/l) was noted in 5 cases. Four patients (4/13) presented a concentration of iron between 11.2 and 20 mmol/l, whereas a high concentration (32.3 mmol/l) was noted in only one case (7.7%).
Conclusion: The study of the biochemical parameters allowed to evaluate the variation of some trace elements in cystic fibrosis and their consequence on the nutritional state of the patients, which constitutes an essential element for the assessment of these patients.

Keywords:

Cystic fibrosis, Trace elements, Proteins, Calcium

##plugins.themes.academic_pro.article.details##

References

  1. Hubert D. Mucoviscidose. Emc-Médicine 2005; 2: 34-41
  2. De Blic J, Le Bourgeois M, Hubert D. Emc, Mucoviscidose. Pneumologie 2001; 6-040-L-25: 14p.
  3. Sernet-Gaudelus I, Lenoir G, Berche P Et Al. Mucoviscidose: Physiopathologie, Génétique, Aspects Cliniques Et Thérapeutiques. Pédiatrie 2002; 4-060-P-10: 23p.
  4. Chaabouni M, Krichen, Ben Halima N Et Al. La Mucoviscidose Chez L'enfant: Expérience D'un Service Tunisien De Pédiatrie Générale. Tun Méd 2004; 82: 516-525.
  5. Federici S, Iron A, Reboul Mp, Desgeorges M, Claustres M, Bremont F, Bieth E. Etude Du Gène Cftr Chez 207 Patients Du Sud-Ouest De La France Atteints De Mucoviscidose: Fréquence Elevée Des Mutations N1303k Et 1811+1,6kba>G. Arch Pédiat 2001; 8: 150-157.
  6. Messaoud T, Bel Hadj Fredj S, Bibi A, Elion J, Ferec C, Fattoum S. Epidémiologie Moléculaire De La Mucoviscidose En Tunisie. Ann Biol Clin 2005 ; 63: 627-30.
  7. Richardson I, Nyulasi I, Cameron K, Ball M, Wilson J. Nutritional Status Of An Adult Cystic Fibrosis Population. Nutrition 2000; 16: 255-259.
  8. Ginies Jl, Bonnemains C. Stratégie De Prise En Charge De La Mucoviscidose. Nutri Clin Métab 2005; 19: 254-59.
  9. Reid Dw, Withers Nj, Francis L, Wilson Jw, Kotsimbos Tc. Iron Deficiency In Cystic Fibrosis: Relationship To Lung Disease Severity And Chronic Pseudomonas aeruginosa Infection. Chest 2002: 121; 48-54.
  10. Reid Dw, Kirov Sm. Iron, Pseudomonas aeruginosa And Cystic Fibrosis. Microbiology 2004; 150: 516-8
  11. Pond Mn, Morton Am, Conway Sp. Functional Iron Deficiency In Adults With Cystic Fibrosis. Respirat Med 1996; 90: 409-13.
  12. Halsted Ja, Smith Jc Jr. Plasma-Zinc In Health And Disease. Lancet 1970; 1: 322-24.
  13. Maqbool A, Schall Ji, Zemel Bs, Garcia-Espana Jf, Stallings Va. Plasma Zinc And Growth Status In Preadolescent Childrenwith Cystic Fibrosis. J Pediatr Gastroenterol Nutr 2006; 43: 95-101.
  14. Van Biervliet S, Van Biervliet Jp, Robberecht E. Serum Zinc In Patients With Cystic Fibrosis At Diagnosis And After One Year Of Therapy. Biol Trace Elem Res 2006; 112:205-211.
  15. Van Biervliet S, Van Biervliet Jp, Velde Sv, Robberecht E. Serum Zinc Concentrations In Cystic Fibrosis Patients Aged Above 4 Years: A Cross-Sectional Evaluation. Biol Trace Elem Res 2007; 119:19-26
  16. Krebs Nf, Sontag M, Accurso Fj, Hambidge Km. Low Plasma Zinc Concentrations In Young Infants With Cystic Fibrosis. J Pediat 1998; 133: 761-64.
  17. Percival Ss, Kauwell Gpa, Bowser E, Wagner M. Altered Copper Status In Adult Men With Cystic Fibrosis. J Am Coll Nutr 1999; 18: 614-619
  18. Gupta A, Eastham Km, Wrightson N, Spencer Da. Hypomagnesaemia In Cystic Fibrosis Patients Referred For Lung Transplant Assessment. J Cyst Fibros 2007; 6:360-62
  19. Holben Dh, Smith Am, Wilmott Rw. Aminoglycosides Lower Serum Magnesium Concentrations In Patients With Cystic Fibrosis: A Retrospective Study. J Am Diet Associa 1995; 95: 1152-1154.