Abrikosoff’s tumor: A clinicopathologic study of nine cases

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Published May 6, 2011
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Vol. 89 No. 5 (2011): Issue May 2011

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Lobna Ayadi
Ines Samet Fakhfakh
Abdelmajid Khabir
Slim Charfi
Ibtissem Bahri
Laboratoire d'Anatomie et de CytologiePathologiques CHU. Habib Bourguiba Sfax-Tunisie
Ahmed Sellami
Mohamed Hédi Abdelmoula
Saloua Makni
Laboratoire d'Anatomie et de Cytologie Pathologiques
Tahya Sellami-Boudawara

Abstract

Background: Abrikossoff’s tumour or granular cell tumor or is a benign neurogenic tumour. It is ubiquitous with the most frequently affected site is the head and neck region.
Aims: To report a series of granular cell tumors and to discuss its clinicopathologic features and histogenesis.
Methods: We report a series of nine cases diagnosed between January 2004 and December 2006 in the Pathology Department of the University Hospital of Sfax. We have collected the clinical aspects and we have proceeded on a pathological, cytochemical (PAS and PAS diastasis) and immunohistochemical study.
Results: Nine cases of TCG are presented: 5 females and 4 males.
The median age was 33.9 years (extremes: 7 and 53 years). All tumours were unique. The most common localization was in the head and neck region (5 cases). The diagnosis was suspected using standard histologic criteria and confirmed by immunohistochemistry: tumour cells expressed vimentine (90%), S100 protein (100%) and neuron specifique enolase (80%). In all cases patients were treated by excisional resection and had a benign course with no evidence of recurrence (median follow up: 2 years).
Conclusion: Granular cell tumours are rare neoplasm which must be recognised because they demonstrate a benign behaviour after their surgical excision. Histological features of granular cell tumours are commonly characteristic but some times they can be misdiagnosed as malignant tumours especially when the biopsy is superficial. The staining for neurogen markers and PAS are useful tools.

Keywords:

Granular cell tumour, Abrikosoff, clinicopathologic findings

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