Radiation therapy in extra abdominal desmoid tumours

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Published Mar 31, 2011
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Vol. 89 No. 4 (2011): Issue Apr 2011

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Dalenda Hentati
Lotfi Kochbati
Asma Belaïd
Jamel Ben Hassouna
Department of surgical oncology
Mongi Maalej

Abstract

Background: Desmoid tumours are rare benign tumours that have local “malignity”. They can be locally aggressive by infiltrating adjacent vascular, nervous and bony structures.
Aim: To define the role of radiotherapy in the management of desmoid tumours.
Methods: Retrospective study of six extra-abdominal desmoid tumours treated with surgery and radiation therapy.
Results: Median age was 26.8 years (16-35 years). The tumor was located in the arm (1 case), in the legs (2 cases) and in the body (3 cases). Median tumoral sizes were 86.6 mm (60-100 mm). Five patients had local recurrence after surgical resection. Radiation therapy included Cobalt 60 in five cases and photons associated to
linear acceleration in one case. Total dose was between 54 and 62 Gy.
At the end of radiation therapy, tumoral control was obtained in five cases after a median follow-up of 26 months (1-83 months).
Conclusion: Surgery is the main treatment of desmoids tumours but local recurrence rates remain high even after complete resection. The role of adjuvant radiation therapy is controversial.

Keywords:

Desmoid tumour, agressive fibromatosis, radiotherapy, treatment,

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References

  1. Jelinek JA, Stelzer KJ, Conrad E et al. The efficacy of radiotherapy as postoperative treatment for desmoid tumors. Int J Radiat Oncol Biol Phys 2001; 50: 121-5.
  2. Henrich MC, Mc Arthur GA, Demetri GD et al. Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor). J Clinical Oncol 2006; 24: 1195- 1203.
  3. Dalén BPM, Bergh PM, Gunterberg BUP. Desmoid tumors. A clinical review of 30 patients with more than 20 years' follow up. Acta Orthop Scand 2003; 74: 455-9.
  4. Nuytens JJ, Rust PF, Thomas CR, Turrisi AT. Surgery versus radiation Therapy for patients with aggressive fibromatosis or desmoid tumors. Cancer 2000; 88: 1517-23.
  5. Ballo MT, Zagars GK, Pollack A, Pisters PWT, Pollock RA. Desmoid tumor: prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol 1999; 17: 158-67.
  6. Halperin EC, Constine LS, Tarbell NJ, Kun LE. Desmoid tumors in « Pediatric Radiation Oncology ». Secon edit. Raven Press. New York. 1994: 352-8.
  7. Cardoso PFG, Da Silva LCC, Bonamigo TP, Geyer G. Intrathoracic desmoid tumor with invasion of the great vessels. Eur J Cardiothrac Surg 2002; 22: 1017-9.
  8. Mc Collough WM, Parsons JJ, Van Dergriend R et al. Radiation Therapy for aggressive fibromatosis: the experience at the university of Florida. J Bone Joint Surg. 1991 ; 73: 717-25.
  9. Aker JC, Bossen EH, Halperin EC. The management of desmoid tumors. Int J Radiat Oncol Biol Phys. 1992; 24(suppl) : 181-2.
  10. Bataïni JP, Belloir C, Mazabrand A et al. Desmoid tumors in adults: the role of Radiotherapy in their management. Am J Surg. 1988; 155 : 754-60.
  11. Greenberg HM, Goebell R, Weichselbum RR et al. Radiation Therapy in the treatment of aggressive fibromatosis. Int J Radiat Oncol Biol Phys. 1981; 7: 305-10.
  12. Gney Y, Hiçsönmez A, Andrieu MN et al. Outcome of aggressive fibromatosis treated with radiation therapy. Scott Ned J 2007; 52: 11-4.
  13. Guadagnolo BA, Zagars GK, Ballo MT. Long-term outcome for desmoid tumors treated with radiation therapy. Int J Radiat Oncol Biol Phys 2007; 69: 1173-80
  14. Gouin F, Tesson A, Bertrand-Vasseur A et al. Rating of tumoral growth in non-operated primary or recurrent extra abdominal aggressive fibromatosis. Rev Chir Orthop Reparatrice Appar Mot 2007; 93: 546-54.
  15. Seinfeld J, Kleinschmidt-DeMasters BK, Tayal S et al. Desmoidtype fibromatosis involving the brachial plexus. Neurosurg Focus 2007; 22: E22.
  16. Baumert BG, Saphr MO, Von Hochstetter A et al. The impact of radiotherapy in the treatment of desmoid tumours. An international survey of 110 patients. A study of the rare cancer network. Radiat Oncol 2007; 2: 12
  17. Seoud M, Abbas J, Kaspar H, Khalil A, Geara F. Long-term survival following aggressive surgery and radiotherapy for pelvic fibromatosis. Int J Gynecol Cancer 2005; 15: 1112-4.
  18. Guadagnolo BA, Zagars GK, Ballo MT. Long-term outcomes for desmoid tumors treated with radiation therapy. Int J Radiat Oncol Biol Phys. 2008; 71: 441-7
  19. Ballo MT, Zagars GK, Pollack A. Radiation Therapy in the management of desmoid tumors. Int J Radiat Oncol Biol Phys. 1998; 42: 1007-11.
  20. Goy BW, Lee SP, Eilbert F et al. The role of adjuvant Radiotherapy in the treatment of resectable desmoid tumors. Int J Radiat Oncol Biol Phys. 1997; 39: 659-65.
  21. Keus R, Bartelink H. The role of radiotherapy in the treatment of desmoid tumors. Radiother Oncol. 1986; 7: 1-5.
  22. Spear MA, Jenings LC, Mankin HJ et al. Individualizing management of aggressive fibromatosis. Int J Radiat Oncol Biol Phys. 1998; 40: 637-45.
  23. Markhede G, Lundgren L, Bjurstam N et al. Extraabdominal desmoid tumors. Acta Orthop Scand. 1986; 57: 1-7.
  24. Merchant TE, Nguyen D, Walter AW et al. Long term results with Radiation Therapy for pediatric desmoid tumors. Int J Radiat Oncol Biol Phys. 2000; 47: 1267-71.
  25. Romero JA, Kim EE, Chung CG et al. Different biologic features of desmoid tumors in adult and juvenile patients: MR demonstration. J Comput Assist Tomogr. 1995; 19: 782-7.
  26. Luop M, Gomperts B, Imren S et al. Differences in expression of matrix metalloproteinases, metalloproteinase inhibitors and plasminogen activators in cultured ovarian cystadenomas, tumors of low-malignant potential and carcinomas. Proc Annu Meet Am Assoc Cancer Res. 1997; 38: A2764.
  27. Zelefsky MJ, Harrisson LB, Shiu MH et al. Combined surgical resection and Iridium implantation for locally advanced and recurrent desmoid tumors. Cancer 1991; 67: 380-4.
  28. Plukker JT, Van Oort I, Vermey A et al. Aggressive fibromatosis: therapeutic problems and the role of adjuvant Radiotherapy. Br j Surg 1995; 82: 510-4.
  29. Ishizuka M, Hatori M, Dohi O et al. Expression profiles of sex steroid receptors in desmoid tumors. Tohoku J Exp Med 2006; 210: 189-98.
  30. Ohashi DT, Shigematsu N, Kameyama K, Kubo A. Tamoxifen for recurrent desmoid tumor of the chest wall. Int J Clin Oncol 2006; 11: 150-2.
  31. Rosato L, Mondini G, Serbelloni M et al. Intra-abdominal desmoid tumors: rare but important disease. G Chir 2007; 28: 20- 4.
  32. Dina lev- Lev D, Kotilingam D, Wei C et al. Optimizing treatment of desmoid tumors. J Cin Oncol 2007; 25: 1785-91.
  33. Talon S, Shanks JH, Loh MY et al. Fibromatosis: benign by name but not necessarely by nature. Clin Oncol 2007; 19: 319-26.
  34. Morris LG, Sikora AG, Kuriakosa MA et al. Tamoxifen therapy for aggressive fibromatosis of the posterior triangle of the neck. Otolaryngol Head Neck Surg 2007; 136: 674-6.
  35. Gega- Gega M, Yanagi H, Yoshikawa R at al. successful chemotherapeutic modality of doxorubicin plus dacarbazin for the treatment of desmoid tumors in association with familial adenomatous polyposis. J Clin Oncol 2006; 24: 102-5.
  36. Skapek SX, Ferguson WS, Granowetter L et al. Vinblastin and methotrexate for desmoid fibromatosis in children: a pediatric oncology group phase II trial. J Clin Oncol 2007; 25: 501-6.
  37. Wcislo G, Szarlej-Wcislo K, Szczylik C. Control of aggressive fibromatosis by treatment with imatinib mesylate. A case report and review of the literature. J Cancer Res Clin Oncol 2007; 133: 533-8.