Autoimmune pancreatitis : A systematic review

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Published Mar 2, 2011
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Vol. 89 No. 3 (2011): Issue Mar 2011

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Lamia Kallel
Narjess Naija
Jalel Boubaker
Azza Filali

Abstract

Background: Autoimmune pancreatitis represents a recently described subset of chronic pancreatitis.
Aim: To determine etiopathogenic features as well as histologic, morphologic, clinical and therapeutic characteristics of autoimmune pancreatitis.
Methods: The study was based on a review of all relevant studies published in the literature on autoimmune pancreatitis before august 2008.
Results: Autoimmune pancreatitis is now considered as the pancreatic manifestation of a systemic disorder that affects various organs, including the bile duct, retroperitoneum, kidney, and parotid and lachrymal glands. A dense lymphoplasmocytic infiltration with IgG4 positive plasma cells and fibrosis are the histological common feature of this systemic disease. Autoimmune pancreatitis is a rare disease that occurs predominantly in elderly men. Its diagnosis is sometimes difficult and can mimic pancreatic cancer whereas its lesions respond so readily to steroids. Thus, diagnostic criteria where developed so that to provide a secure basis for diagnosis and avoid abusive pancreatic resections.
Conclusion: Since its individualisation, interest in autoimmune pancreatitis has grown and many clinical aspects have been clarified.

Keywords:

Autoimmune pancreatitis, chronic pancreatitis, IgG4 related sclerosing disease

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References

  1. Sarles H, Sarles JC, Muratore R, Guien C. Chronic inflammatory sclerosis of the pancreas--an autonomous pancreatic disease? Am J Dig Dis 1961; 6: 688-98.
  2. Epstein O, Chapman RW, Lake-Bakaar G, Foo AY, Rosalki SB, Sherlock S. The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis. Gastroenterology 1982; 83:117-82.
  3. Montefusco PP, Geiss AC, Bronzo RL, Randall S, Kahn E, McKinley MJ. Sclerosing cholangitis, chronic pancreatitis, and SjS: A syndrome complex. Am J Surg 1984; 147:822-6.
  4. Lankisch PG, Koop H, Seelig R, Seelig HP. Antinuclear and pancreatic acinar cell antibodies in pancreatic disease. Digestion 1981; 21:65-8.
  5. Kawaguchi K, Koike M, Tsuruta K, Okamoto A, Tabata I, Fujita N. Lymphoplasmacytic sclerosing pancreatitis with cholangitis: A variant primary sclerosing cholangitis extensively involving pancreas. Hum Pahtol 1991; 22:387-95.
  6. Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality.Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci 1995; 40: 1561-8.
  7. Church NI, Pereira SP, Deheragoda MG et al. Autoimmune pancreatitis: Clinical and radiological features and objective response to steroid therapy in a US series. Am J Gastroenterol 2007; 102:2417-25.
  8. Nishimori I, Tamakoshi A, Otsuki M; Research Committee on Intractable Diseases of the Pancreas, Ministry of Health, Labour, and Welfare of Japan. Prevalence of autoimmune pancreatitis in Japan from a nationwide survey in 2002. J Gastroenterol 2007; 42:6-8.
  9. Chari ST, Smyrk TC, Levy MJ et al. Diagnosis of autoimmune pancreatitis: The Mayo Clinic experience. Clin Gastroenterol Hepatol 2006; 4:1010-6.
  10. Kamisawa T. IgG4-related sclerosing disease. Intern Med 2006; 45:125-6.
  11. Pearson RK, Longnecker DS, Chari ST, et al. Controversies in clinical pancreatology. Autoimmune pancreatitis: does it exist? Pancreas 2003; 27:1-13.
  12. Kim KP, Kim MH, Song MH, Lee SS, Seo DW, Lee SK. Autoimmune chronic pancreatitis. Am J Gastroenterol 2004;99:1605-16.
  13. Weber SM, Cubukcu-Dimopulo O, Palesty JA et al. Lymphoplasmacytic sclerosing pancreatitis: inflammatory mimic of pancreatic carcinoma. J Gastrointest Surg 2003; 7:129-37.
  14. Abraham SC, Wilentz RE, Yeo CJ et al. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they all ‘‘chronic pancreatitis''? Am J Surg Pathol 2003; 27:110-20.
  15. Farnell MB, Pearson RK, Sarr MG et al. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 2005;138: 618-28.
  16. Finkelberg DL, Sahani D, Deshpande V, Brugge WR. Autoimmune pancreatitis. N Engl J Med 2006 21; 355:2670-6.
  17. Yadav D, Notahara K, Smyrk TC et al. Idiopathic tumefactive chronic pancreatitis: clinical profile, histology, and natural history after resection. Clin Gastroenterol Hepatol 2003;1:129- 35.
  18. Raina A, Yadav D, Krasinskas AM. Autoimmune pancreatitis. N Engl J Med 2007 12; 356:1587.
  19. Kamisawa T, Yoshiike M, Egawa N, et al. Chronic pancreatitis in the elderly in Japan. Pancreatology 2004; 4:223-7.
  20. Blejter J, Weller S, Pace R, Cusumano H, Giambini D. Autoimmune pancreatitis: an adolescent case and review of literature. J Pediatr Surg. 2008; 43:1368-72.
  21. Kamisawa T, Wakabayashi T, Sawabu N. Autoimmune pancreatitis in young patients. J Clin Gastroenterol 2006; 40:847-50.
  22. Ota M, Katsuyama Y, Hamano H et al. Two critical genes (HLADRB1 and ABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis. Immunogenetics 2007; 59:45-52.
  23. Umemura T, Ota M, Hamano H, et al. Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients. Gut 2006; 55:1367-8.
  24. Chang MC, Chang YT, Tien YW, et al. T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis. Clin Chem 2007; 53:1700-5.
  25. Umemura T, Ota M, Hamano H, et al. Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients. Am J Gastroenterol 2008; 103:588-94.
  26. Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001; 344:732-8.
  27. Zhang L, Notohara K, Levy MJ, Chari ST, Smyrk TC. IgG4- positive plasma cell infiltration in the diagnosis of autoimmune pancreatitis. Mod Pathol 2007; 20:23-8.
  28. Kamisawa T, Funata N, Hayashi Y, et al. Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis. Gut 2003; 52:683-7.
  29. Kamisawa T, Egawa N, Nakajima H et al. Gastrointestinal findings in patients with autoimmune pancreatitis. Endoscopy 2005; 37:1127-30.
  30. Kamisawa T, Nakajima H, Egawa N, Hayashi Y, Funata N. Autoimmune pancreatitis can be confirmed with gastroscopy. Dig Dis Sci 2004; 49:155-6.
  31. Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol 2003; 38:982-4.
  32. Kamisawa T, Nakajima H, Egawa N, Funata N, Tsuruta K, Okamoto A. IgG4-related sclerosing disease incorporating sclerosing pancreatitis, cholangitis, sialadenitis and retroperitoneal fibrosis with lymphadenopathy. Pancreatology 2006; 6:132-7.
  33. Ghazale A, Chari ST, Smyrk TC et al. Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer. Am J Gastroenterol 2007;102:1646-53.
  34. Okazaki K, Uchida K, Ohana M, et al. Autoimmune-related pancreatitis is associated with autoantibodies and Th1/Th2-type cellular immune response. Gastroenterology 2000; 118:573-81.
  35. Kountouras J, Zavos C, Gavalas E, et al. Challenge in the pathogenesis of autoimmune pancreatitis: potential role of helicobacter pylori infection via molecular mimicry. Gastroenterology 2007; 133:368-9.
  36. Timothy B, Garner, MD, Suresh T, Chari MD. Autoimmune pancreatitis. Gastroenterol Clin N Am 2008; 37: 439-60.
  37. Okazaki K, Uchida K, Fukui T. Recent advances in autoimmune pancreatitis: concept, diagnosis, and pathogenesis. J Gastroenterol 2008; 43:409-18.
  38. Zamboni G, Lüttges J, Capelli P, et al. Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens. Virchows Arch 2004; 445:552-63.
  39. Kawaguchi K, Koike M, Tsuruta K et al. Lymphoplasmacytic sclerosing pancreatitis with cholangitis: a variant of primary sclerosing cholangitis extensively involving pancreas. Hum Pathol 1991; 22:387-95.
  40. Shimoda M, Kubota K, Sawada T, et al. Autoimmune pancreatitis diagnosed on the basis of immunohistology alone. A case report. JOP 2006; 7:478-81.
  41. Ectors N, Maillet B, Aerts R, et al. Nonalcoholic duct destructive chronic pancreatitis. Gut 1997; 41: 263-8.
  42. Lara LP, Chari ST. Autoimmune pancreatitis. Curr Gastroenterol Rep 2005;7: 101-6.
  43. Levy MJ, Reddy RP, Wiersema MJ, et al. EUS-guided trucut biopsy in establishing autoimmune pancreatitis as the cause of obstructive jaundice. Gastrointest Endosc 2005; 61:467-72.
  44. Kloppel G, Sipos B, Zamboni G, et al. Autoimmune pancreatitis: histo- and immunopathological features. J Gastroenterol 2007; 42:28-31.
  45. Takayama M, Hamano H, Ochi Y, et al. Recurrent attacks of autoimmune pancreatitis result in pancreatic stone formation. AmJ Gastroenterol. 2004; 99:932-7.
  46. Hirano K, Tada M, Isayama H, et al. Long-term prognosis of autoimmune pancreatitis with and without corticosteroid treatment. Gut 2007; 56:1719-24.
  47. Kamisawa T, Okamoto A. Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease. J Gastroenterol 2006; 41:613-25.
  48. Nahon Uzan K, Levy P, O'Toole D, et al. Is idiopathic chronic pancreatitis an autoimmune disease? Clin Gastroenterol Hepatol 2005; 3:903-9.
  49. Chari ST. Diagnosis of autoimmune pancreatitis using its five cardinal features: introducing the Mayo Clinic's HISORt criteria. J Gastroenterol 2007; 42:39-41.
  50. Sahani DV, Kalva SP, Farrell J et al. Autoimmune pancreatitis: imaging features. Radiology 2004; 233:345-52.
  51. Okazaki K, Uchida K, Matsushita M et al. How to diagnose autoimmune pancreatitis by the revised Japanese clinical criteria. J Gastroenterol 2007; 42:32-8.
  52. Horiuchi A, Kawa S, Hamano H, Hayama M, Kiyosawa K. ERCP features in 27 patients with autoimmune pancreatitis. Gastrointest Endosc 2002; 55:494-9.
  53. Kim MH, Kim KP, Lee YJ et al. 17 cases of chronic autoimmune pancreatitis. Korean J Intern Med 2003; 65: 94.
  54. Kamisawa T, Egawa N, Inokuma S, et al. Pancreatic endocrine and exocrine function and salivary gland function in autoimmune pancreatitis before and after steroid therapy. Pancreas 2003; 27:235-8.
  55. Kamisawa T, Nakamura T, Egawa N, Nakajima H, Tsuruta K, Okamoto A. Digestion and absorption of patients with autoimmune pancreatitis. Hepatogastroenterology 2006; 53:138-40.
  56. Nishino T, Toki F, Oyama H, Shimizu K, Shiratori K. Long-term outcome of autoimmune pancreatitis after oral predonisolone therapy. Intern Med 2006; 45:497-501.
  57. Kawa S, Hamano H. Autoimmune pancreatitis and bile duct lesions. J Gastroenterol 2003; 38:1201-3.
  58. Kamisawa T, Egawa N, Nakajima H, Tsuruta K, Okamoto A, Kamata N. Clinical difficulties in the differentiation of autoimmune pancreatitis and pancreatic carcinoma. Am J Gastroenterol 2003; 98:2694-9.
  59. Nishimori I, Miyaji E, Morimoto K, Nagao K, Kamada M, Onishi S. Serum antibodies to carbonic anhydrase IV in patients with autoimmune pancreatitis. Gut 2005; 54:274-81
  60. Asada M, Nishio A, Uchida K, et al. Identification of a novel autoantibody against pancreatic secretory trypsin inhibitor in patients with autoimmune pancreatitis. Pancreas 2006; 33:20-6.
  61. Uchida K, Okazaki K, Asada M, Yazumi S, Ohana M, Chiba T. Case of chronic pancreatitis involving an autoimmune mechanism that extended to retroperitoneal fibrosis. Pancreas 2003; 26: 92-4.
  62. Hamano H, Arakura N, Muraki T et al. Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis. J Gastroenterol 2006; 41:1197-205.
  63. Hirano K, Shiratori Y, Komatsu Y et al. Involvement of the biliary system in autoimmune pancreatitis: a follow-up study. Clin Gastroenterol Hepatol 2003; 1:453-64.
  64. Bjornsson E, Chari ST, Smyrk TC et al. Immunoglobulin G4 associated cholangitis: description of an emerging clinical entity based on review of the literature. Hepatology 2007;45:1547-54
  65. Nishino T, Toki F, Oyama H et al. Biliary tract involvement in autoimmune pancreatitis. Pancreas 2005; 30:76-82.
  66. Saeki T, Nishi S, Ito T, et al. Renal lesions in IgG4-related systemic disease. Intern Med 2007; 46:1365-71.
  67. Hamano H, Kawa S, Ochi Y et al. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet 2002; 359:1403-4.
  68. Khalili K, Doyle DJ, Chawla TP et al. Renal cortical lesions in patients with autoimmune pancreatitis: a clue to differentiation from pancreatic malignancy. Eur J Radiol. 2008; 67:329-35.
  69. Sasahira N, Kawabe T, Nakamura A et al. Inflammatory pseudotumor of the liver and peripheral eosinophilia in autoimmune pancreatitis. World J Gastroenterol 2005; 11: 922-5.
  70. Japan Pancreas Society. Diagnostic criteria for autoimmune pancreatitis by the Japan Pancreas Society (2002). J Jpn Pancreas Soc 2002; 17:585-7.
  71. Okazaki K, Kawa S, Kamisawa T, et al. M; Research Committee of Intractable Diseases of the Pancreas. Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal. J Gastroenterol 2006; 41:626-31.
  72. Otsuki M, Chung JB, Okazaki K, et al. Research Committee of Intractable Pancreatic Diseases provided by the Ministry of Health, Labour and Welfare of Japan and the Korean Society of Pancreatobiliary Diseases. Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis. J Gastroenterol 2008; 43:403-8.
  73. Ghazale A, Chari ST. Optimising corticosteroid treatment for autoimmune pancreatitis. Gut 2007; 56:1650-2.
  74. Ito T, Nishimori I, Inoue N, et al. Treatment for autoimmune pancreatitis: consensus on the treatment for patients with autoimmune pancreatitis in Japan. J Gastroenterol 2007 ;42:50-8.
  75. Kamisawa T, Yoshiike M, Egawa N, et al. Treating patients with autoimmune pancreatitis: results from a long-term follow-up study. Pancreatology 2005; 5:234-8.
  76. Nishimori I, Okazaki K, Suda K, et al. Treatment for autoimmune pancreatitis. J Jpn Pancreas Soc 2005; 20:343-8.
  77. Hirano K, Tada M, Isayama H, et al. Long-term prognosis of autoimmune pancreatitis with and without corticosteroid treatment. Gut 2007; 56:1719-24.
  78. Matsushita M, Ikeura T, Fukui T, Uchida K, Okazaki K. Refractory autoimmune pancreatitis: azathioprine or steroid pulse therapy? Am J Gastroenterol 2008; 103: 1834.
  79. Ghazale A, Chari ST, Zhang L, et al. Immunoglobulin G4- associated cholangitis: clinical profile and response to therapy. Gastroenterology 2008; 134:706-15
  80. Kamisawa T, Okamoto. A Prognosis of autoimmune pancreatitis. J Gastroenterol 2007; 42:59-62.
  81. Park do H, Kim MH, Oh HB, et al. Substitution of aspartic acid at position 57 of the DQbeta1 affects relapse of autoimmune pancreatitis. Gastroenterology 2008; 134:440-6
  82. Floyd A, Pedersen L, Nielsen GL. Risk of acute pancreatitis in uses of azathioprine: A population-based case-control study. Am J Gastroenterol 2003; 98:1305-8.
  83. Church NI, Webster GJ. Autoimmune Pancreatitis: Optimal Therapy Has Not Been Determined. Am J Gastroenterol 2008; 103:1834-5.
  84. Fukui T, Mitsuyama T, Takaoka M, Uchida K, Matsushita M, Okazaki K. Pancreatic cancer associated with autoimmune pancreatitis in remission. Intern Med 2008; 47:151-5.