Early neonatal infection caused by Streptococcus pneumonias: report of 3 cases

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Published Feb 8, 2011
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Vol. 89 No. 2 (2011): Issue Feb 2011

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Asma Bouziri
Sarra Bel Hadj
Ammar Khaldi
Aida Borgi
Khaled Menif
Nejla Ben Jaballah

Abstract

Background: S pneumoniae is a rare cause (1-8 %) of maternofetal infection causing an important morbi-mortality in the newborn and the mother.
Aim: To report 3 cases of early neonatal infection due to S pneumonia.
Cases report : Three cases of early neonatal infection due to S pneumoniae are reported. The three newborns were at term or near term babies with a vaginal delivery in two cases and a caesarean section in one case. They presented severe symptoms, with a progressive onset after birth, leading to hypoxemic pneumonia in one case and to septic shock in two newborns associated with meningitis in one case. S pneumoniae was isolated in the blood culture in two
patients with positive soluble antigens in the cerebrospinal fluid in one case and positive peripheral bacteriological swabs in the other case. In the third case, S pneumoniae was isolated in the tracheal sample of the newborn and his mother. S pneumoniae was sensitive to ampicillin in two patients and of decreased sensitivity to ampicillin in one patient. The clinical course was favourable in the three patients after hospitalization in the intensive care unit.
Conclusion: Early neonatal infections caused by S pneumonia are rare and are an important cause of morbi-mortality in the newborn and the mother.

Keywords:

streptococcus pneumoniae, neonatal infection, perinatal transmission.

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References

  1. Nader R, Tondeur S, Barrans A, Gevaudan A, Lamy B. streptococcus pneumoniae neonatal infection. Ann Biol Clin 2005; 63: 643- 46.
  2. Bamford C, Whitelaw A, Haffejee S. streptococcus pneumoniae infections in neonates. S Afr Med J 2007; 97:10-11.
  3. Geelen Sp, Gerards Lj, Fleer A. Pneumococcal septicemia in the newborn. A report on seven cases and a review of the literature. J Perinat Med 1990; 18:125-29.
  4. Gomez M, Alter S, Kumar Ml, Murphy S, Rathore MH. Neonatal streptococcus pneumoniae infection: case reports and review of the literature. Pediatr Infect Dis J 1999; 18:1014-18.
  5. Marcus Ka, Verduin Cm, Halbertsma FJ. Invasive pneumococcal infection in 5 newborns, 1996-2004. Ned Tijdschr Geneeskd 2007; 151: 2527-30.
  6. Primhak Ra, Tanner Ms, Spencer Rc. Pneumococcal infection in the newborn. Arch Dis Child 1993; 69: 317-18.
  7. Mcadams Rm, Garza-Cox S, Yoder BA. Early-onset neonatal pneumococcal sepsis syndrome. Pediatr Crit Care Med 2005; 6: 595-97.
  8. Sakran W, Valinsky L, Koren A, Bor N, Yishai R, Colodner R. Early onset of neonatal streptococcus pneumoniae bacteremia and septic arthritis. Clin Pediatr (Phila) 2004; 43: 579-81.
  9. Nallusamy R. Fatal early-onset neonatal sepsis due to streptococcus pneumoniae. Med J Malaysia 1998; 53: 442-45.
  10. Hoffman Ja, Mason Eo, Schutze GE et al. streptococcus pneumoniae infections in the neonate. Pediatrics 2003; 112:1095-102.
  11. Strobel M, Rosenthal Jm, Adjide C, Perez Jm, Janky E. Pneumococcus: an unusual agent of maternal-fetal infection. Presse Med 1999; 28: 2100-102
  12. Pavis A, Cortey A, Lozniewski A, Weber M, Vert P. Early-onset septicemia in a newborn due to a penicillin resistant pneumococcus probably transmitted during delivery. Eur J Clin Microbiol Infect Dis 1995; 14: 68-69.
  13. Johnsson H, Bergström S, Ewald U, Schwan A. Two cases of neonatal pneumococcal septicemia. Acta Obstet Gynecol Scand 1992; 71:72-73.
  14. Robinson EN JR Pneumococcal endometritis and neonatal sepsis. Rev Infect Dis 1990; 12:799-801.
  15. Westh H, Skibsted L, Korner B. streptococcus pneumoniae infections of the female genital tract and in the newborn child. Rev Infect Dis 1990; 12: 416-22.
  16. Bortolussi R, Thompson Tr, Ferrieri P. Early-onset pneumococcal sepsis in newborn infants. Pediatrics 1977; 60: 352-55.
  17. Khan A, Coughtrey H, Leroi MJ. streptococcus pneumoniae: uncommon cause of fatal neonatal sepsis. J Paediatr Child Health 2009; 45: 686-7.