Sugar tumor

##plugins.themes.academic_pro.article.main##

Sonia Sanai Raggad
Anissa Zouaoui
Nadia Mehiri
Jouda Chérif
Hafedh Zakhama
Mohamed Nidhameddine Kchir
Mounir Dhiab
Jalloul Daghfous
Béchir Louzir
Majed Béji

Abstract

Background: Clear cell tumor of the lung is a rare and very unusual benign pulmonary tumor. This tumor is called sugar tumor because of the abundance of glycogen on its cells.
Aim: To report a case of sugar tumor and discuss clinical, evolutive features and diagnosis difficulties of this tumor.
Case report: A case of 75 years old woman presenting as a round pulmonary opacity. Computed tomography (CT) scans showed in the left lower lobe a solitary pulmonary solid tumor with central calcifications. The patient underwent tumor resection. Pathologic examination, including immunohistochemical studies, revealed a benign clear cell tumor, so-called “sugar tumor”.
Conclusion: It’s the second case reported in Tunisia. This very rare tumor of the lung is characterized by some immunohistological features. Its evolution is favourable after surgery.

Keywords:

Clear cell tumor, Sugar tumor, Surgery, HMB-45

##plugins.themes.academic_pro.article.details##

References

  1. Liebow Aa, Castleman B. Benign “clear cell tumors” of the lung. Am J Pathol 1963; 43: 13-4.
  2. Liebow Aa, Castleman B. Benign clear cell (“sugar”) tumors of the lung. Yale J Biol Med 1971; 43: 213-22.
  3. Gaffey Mj, Mills Se, Zarbo Rj, Weiss Lm, Gown AM. Clear cell tumor of the lung. Immunohistochemical and ultrastructural evidence of melanogenesis. Am J Surg Pathol 1991; 15: 644-53.
  4. Travis Wd, Brambilla E, Muller-Hermelink Hk, Harris CC. World Health Organisation classification of tumours. Patholology and genetics of tumours of the lung, pleura, thymus and heart, Lyon: IARC Press, 2004:118.
  5. Gal Aa, Koss Mn, Hochhlzer L, Chejfec G. An immunohistochemical study of benign clear cell (“sugar”) tumor of the lung. Arch Pathol Lab Med 1991; 115:1034-8.
  6. Pea M, Bonetti F, Zamboni G, Martignoni G, Doglioni C, Fiore- Donati L. Clear cell tumor and angiomyolipoma [Letter]. Am J Surg Pathol 1991; 115:199-202.
  7. Santana An, Nunes Fs, Ho N, Takagaki TY. A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung. Eur J Cardiothorac Surg 2004; 25: 652-4.
  8. Seo Jb, Im Jg, Seo Jw, Yeon KM. Clear cell tumor of the lung. AJR Am J Roentgenol 1996; 166: 730-1.
  9. Woong Jk, So Rk, Yrong HC et al. Clear Cell “Sugar” Tumor of the Lung: A Well-Enhanced Mass with an Early Washout Pattern on Dynamic Contrast-Enhanced Computed Tomography. J Korean Med Sci 2008; 23: 1121-4.
  10. Eichler B, Loubet A, Leboutet Mj, Germouty J, Loubet R. Clear cell tumor of the lung (sugar tumor), Study of a case. Arch Anat Cytol Pathol 1991; 39: 83-7.
  11. Gown Am, Vogel Am, Hoak D, Gough F, Mcnutt MA. Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes. Am J Pathol 1986; 123: 195-203
  12. Gaffey Mj, Mills Se, Askin FB et al. Clear cell tumor of the lung. A clinicopathologic, immunohistochemical, and ultrastructural study of eight cases. Am J Surg Pathol 1990; 14: 248-59.
  13. Gaffey Mj, Mills Se, Ritter JH. Clear cell tumors of the lower respiratory tract. Semin Diagn Pathol 1997; 14: 222-32.
  14. Henry Dt, Kenneth Pb, John RS. Primary Extrapulmonary Sugar Tumor (PEST): A Report of Four Cases. Mod Pathol 2001; 14: 615-22.
  15. Masur Y, Becker Hp, Fackeldey V. Sugar tumor. Rare differential diagnosis of pulmonary clear cell tumor after renal carcinoma. Urologe A 2003; 42: 1250-4.
  16. Ayadi-Kaddour A, Ben Slama A, Braham E et al. La tumeur à cellules claires du poumon : A propos d'un cas avec revue de la littérature. Rev Pneumol Clin 2006; 62: 395-8.