Changes in serum lipids in patients with colorectal Cancer

##plugins.themes.academic_pro.article.sidebar##

Published Feb 4, 2011
Download
pdf
Vol. 89 No. 2 (2011): Issue Feb 2011

##plugins.themes.academic_pro.article.main##

Hajer Abaza
Abderraouf Ghanem
Aouatef Jmal
Latifa Harzallah
Khaled Rahal
Fethi Guemira

Abstract

Aim: To evaluate and assess disruptions of serum lipids at patients having a colorectal cancer.
Methods: Our prospective study interested 30 patients, from 26 to 93 year old, presenting a colorectal cancer confirmed histologically, examined during the period going from March 2003 to April 2004.
Thirty healthy controls were examined in parallel. All patients undergo three blood samples respectively in preoperative, 48h and 6 months after surgical operation. The analyses carried out were determination of a total serum cholesterol, HDL (high density lipoprotéin) and LDL (low density lipoprotein) cholesterol, serum triglyceride and serum apoprotein (AI and B)
Results: We noticed a decrease of total serum cholesterol level in 43% of the cases associated to the reduction of the HDL and the LDL cholesterol in respectively 30% and 76% of cases. The mean values of total serum cholesterol, HDL and LDL cholesterol rates were significantly lower for patients compared to those of controls (p respectively : 0.001; 0.04 and 0.001). Moreover, the level of total serum cholesterol varied significantly with tumor localization ( p= 0,02).
Conclusion: Serum lipid disruptions affect essentially total cholesterol, HDL and LDL cholesterol. It would be therefore interesting to evaluate their rate at the basal state in order to follow their evolution after treatment in colorectal cancer.

Keywords:

Colorectal cancer, serum lipids

##plugins.themes.academic_pro.article.details##

References

  1. Jiang JT, Xu N, Zhang XY, Wu CP. Lipids changes in liver cancer. J Zhejiang Univ Sci B 2007; 8: 398-409.
  2. O'Rourke JS, Jhonson A, Collins P, Bouchier D. An association between hypocholesterolemia and colorectal carcinoma in an Irish population. Gut 1992; 33:950-3.
  3. Patel P, Shah M, Jha F, et al. Alteration in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer 2004; 4; 25-31.
  4. Iribarren C, Reed D, Chen R, Yano K, Dwyer J. Low cholesterol and mortality. Which is the cause and which is the effect? Circulation 1995; 92:2396-2403.
  5. Aixala M, Sarandria CN, Speroni JG. Hypocholestérolémie in hematologic neoplasms. Sangre 1997;42:7-10.
  6. Avall Eh, Peterson C. Serum cholesterol and apolipoprotein B levels may reflect disease activity in ovarian cancer patients. Acta Oncol 1996;35:1007-10.
  7. Forones N, Falcao J, Mattos D, Barone B. Cholesterolemia in colorectal cancer. Hepatogastroenterology 1998;45:1531-4.
  8. Fiorenza A, Branchi A, Sommariva D. Serum lipoprotein profile in patients with cancer. A comparison with non cancer subjects. Int J Clin Lab Res 2000;30:141-5.
  9. Jiang JT, Xu N, Wu CP. Metabolism of high density lipoprotein in liver cancer. World J Gastroenterol 2007; 13: 3159-63.
  10. Rast AS, Naik PP. Clinical significance of lipid profile in cancer patients. Indian J Med Sci 2000;54:435-41.
  11. Rast AS, Naik PP. Clinical significance of lipid profile in cancer patients. Indian J Med Sci 2000;54:435-41.
  12. Gaard M, Tretli S, Urdal P. Blood lipid and lipoprotein levels and the risk of cancer of the colon and rectum. A prospective study of 62,173 Norwegian men and women. Scand J Gastroenterology 1997;32:162-8.
  13. Siemianowicz K, Gminski J, Stajszczyk M. Serum total cholesterol and triglycerides levels in patient with lung cancer. Int J Mol Med 2000; 5:201-5.
  14. Markel A, Brook GJ. Cancer and hypocholesterolemia. Isr J Med Sci 1994;30:787-93.
  15. Sassolas A, Carter R. Les hypocholestérolémies : causes et diagnostic. Ann Biol Clin 1999;57 :555-60.
  16. Cambien F, Ducimétière P, Richard Jl. Total serum cholesterol and cancer mortality in a middle-aged male population. Am J Epidemiol 1980;112:943-8.
  17. SchliengerJL, Goichot B, Pradignac A. Cholestérolémie et pathologie : le point. Rev Méd Interne 1998;19 :180-4.
  18. Fuhrman B, Wolfovitz E, Cogan U, Brook G. Hypocholesterolemia and cancer: tumor cells induce enhanced LDL uptake by non-tumor cells and stimulate oxidative modifications of LDL. Pathophysiology 1999;6:205-10.
  19. Tomiki Y, Suda S, Tanaka M, Okuzawa A, Matsuda M. Reduced low-density- lipoprotein cholesterol causing low serum cholesterol levels in gastrointestinal cancer: a case control study. J Exp Clin Cancer Res 2004;23:233-40.
  20. Notarnicola M, Altomare DF, Correale M, Ruggieri E, D'Attoma B. Serum lipid in colorectal cancer patients with and without synchronous distant metastases. Oncology 2005; 68: 371-4.
  21. Gluek Cj, Kelley W, Gupta A Fontaine RN. Prospective 10 years evaluation of hypobetalipoproteinemia in a cohort of 772 fire fighters and cross-sectional evaluation of hypocholesterolemia in 1479 men in the national health and nutrition examination survey. Metabolism 1997;46:625-33.