Hepatocellular Carcinoma with sarcomatous change

##plugins.themes.academic_pro.article.sidebar##

Published Dec 2, 2010
Download
pdf
Vol. 88 No. 12 (2010): Issue Dec 2010

##plugins.themes.academic_pro.article.main##

Yosra Said
Senda Trabelsi
Nadia Kourda
Radhouane Debbeche
Slim Bouzaidi
Mohammed Salem
Taoufik Najjar

Abstract

Background : Hepatocellular carcinoma (HCC) with sarcomatous change is an uncommon neoplasm with a poor prognosis.
Aim: To report a new case
Case report: A 72-year-old man presented with abdominal right upper quadrant pain. The diagnosis of cirrhosis was suspected on clinical and biochemical data. On abdominal computed tomography, the mass was not enhanced in the arterial phase and exhibited peripheral enhancement during portal phase which persisted in the delayed phase. The serum alpha-fetoprotein was 500 ng/ml but since the imaging features were not typical of ordinary HCC, percutaneous liver biopsy was performed and confirmed the diagnosis of HCC with sarcomatous change
Conclusion: Except for liver biopsy, no diagnostic method could distinguish between sarcomatous and ordinary HCC.

Keywords:

Carcinoma, hepatocellular, sarcoma, liver, biopsy

##plugins.themes.academic_pro.article.details##

References

  1. Kojiro M, Sugihara S, Kakizoe S, Nakashima O, Kiyomatsu K. Hepatocellular carcinoma with sarcomatous change: a special reference to the relationship with anticancer therapy.Cancer Chemother Pharmacol 1989; 23:S4-S8.
  2. Kakizoe S, Kojiro M, Nakashima T. Hepatocellular carcinoma with sarcomatous change. Clinicopathologic and immunohistochemical studies of 14 autopsy cases. Cancer 1987; 59: 310-16.
  3. Maeda T, Adachi E, Kajiyama K, Takenaka K, Sugimachi K, Tsuneyoshi M. Spindle cell hepatocellular carcinoma. A clinicopathologic and immunohistochemical analysis of 15 cases. Cancer 1996; 77: 51-57.
  4. Haratake J, Horie A. An immunohistochemical study of sarcomatoid liver carcinomas. Cancer 1991; 68: 93-7.
  5. Tsujimoto M, Aozasa K, Nakajima Y, Kariya M. Hepatocellular carcinoma with sarcomatous proliferation showing an unusual and wide-spread metastasis. Acta Pathol Jpn 1984; 34: 839-45.
  6. Yamanaka J, Yamanaka N, Nakasho K, et al. Clinicopathologic analysis of stage II-III hepatocellular carcinoma showing early massive recurrence after liver resection. J Gastroenterol Hepatol 2000; 15:1192-98.
  7. Hwang S, Lee SG, Lee YJ, et al. Prognostic impact of sarcomatous change of hepatocellular carcinoma in patients undergoing liver resection and liver transplantation. J Gastrointest Surg 2008; 12:718-24.
  8. Eriguchi N, Aoyagi S, Okuda K, et al. Unusual liver carcinomas with sarcomatous features: analysis of four cases. Surg Today 2001; 31: 530-33.
  9. Honda H, Hayashi T, Yoshida K, et al. Hepatocellular carcinoma with sarcomatous change: characteristic findings of two-phased incremental CT. Abdom Imaging 1996; 21:37-40.
  10. Ueda K, Matsui O, Kawamori Y, et al. Hypervascular hepatocellular carcinoma:evaluation of hemodynamics with dynamic CT during hepaticarteriography. Radiology 1998; 206: 16 -6.