Particularities of pregnancy and labor in 40 -year-old women About 300 cases

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Asma Jnifen
Anis Fadhlaoui
Anis Chaker
Fethi Zhioua

Abstract

Background: Pregnancy beyond age 40 is considered as a high risk pregnancy associated with high rates of maternal and fetal complications.
Aim: To analyze particularities of pregnancy and labor and to examine obstetrical and neonatal outcomes among women age 40 years and older.
Methods : There was a retrospective study including two groups of 300 patients , the first including the 40 -year- old and over women (case group), and the second including 20-to 39 -year -old mothers (control group).
Results: The mean age for the case group was 41 years. Ten (10.6%) of the women in the ca se group were primiparous as compared with twenty-seven (27.5%) in the control one (p=0.001).The antenatal surveillance was better in the control group. The morphologic sonograhy was performed in 73% of cases of 40-year -old -women versus 90% in the control group (p<0.001). Maternal age 40 and over was associated with an increased risk for gestational diabetes (6.4% versus 1.7%, p <0.001). The premature rupture of membranes was frequent in the case group (25.7% versus 11.7% p <0.001), and the amniotic fluid meconuim (16.3% versus 6.7%, p <0.001). The risk for cesarean section was higher in older women (25.7% versus 14% avec p <0.001). Neonatal outcomes (Apgar score, birth weight, perinatal mortality) were similar to those in the younger age group.
Conclusion: The analysis of our results and the review of the literature have proven that advanced-maternal-age-pregnancy is associated with increased complications. So some recommendations’ are necessary to ameliorate the management of this pregnancy.

Keywords:

High risk pregnancy, Age 40 and over-cesarean section,

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References

  1. Bianco A, Stone J, Lynch L, Lapinski R, Berkowitz G, Berkowitz R. Pregnancy outcome at age 40 and older. Obstet Gynecol 1996; 87: 917-922.
  2. Gilbert W, Nesbitt T, Danielson B. Childbearing beyond Age 40 pregnancy outcome in 24032 cases. Obstet Gynecol 1999; 93: 9-14.
  3. Kirz DS, Dorchester W, Freeman RK. Advanced maternal age: the mature gravida. Am J Obstet Gynecol 1985; 152: 7-12.
  4. Tuck R, Yudking P, Turnbul L.Pregnancy outcome in elderly primigravida with and without a history of infertility. Br J Obstet Gynaecol 1988; 95: 230-237.
  5. Flierh R. Management of the elderly primigravida. Obstet Gynecol 1956; 8: 494-499.
  6. Prysak M., Lorenz RP., Kisly A. Pregnancy outcome in nulliparous women 35 years and older. Obstet. Gynecol 1995; 85: 65-70.
  7. Yasin S, Beydoun S. Pregnancy outcome at 20 weeks gestation in women in their 40: case control study. J Reprod Med 1988; 33: 209-213.
  8. Ananth CV, Wilcox AJ., Avitz DA et al. Effect of maternal age and parity on the risk of uteroplacental bleeding disorders in pregnancy. Obstet Gynecol1996; 88: 511-6.
  9. Belaisch-Allart J, Lafay-Pillet MC, Taurelle R. Les grossesses après 40 ans. Reprod Hum Horm 1991; 4: 176-180
  10. Darbois Y, Boulanger MC. Les grossesses survenant après 40ans sont-elles à haut risque. Rev Fr Gynecol Obstet 1990; 85: 158-160.
  11. Adashek JA, Peaceman AM Lopez JA, Minog JP, Min D, Socol ML.Factors contributing to the increased cesarean birth rate in older parturient women .Am J Obstet Gynecol 1993; 168 : 936-40.
  12. Edge VL, Laros RK. Pregnancy outcome in nulliparous women aged 35 or older .Am J Obstet Gynecol 1993; 168: 1881-5.
  13. Bréart G. Delayed childbearing. Eur J Obstet Gynecol Reprod Biol 1997; 75: 71-3.
  14. Roman H, Robillard P, Julien C, Kaufmann E, Laffitte A, Gabriele M. Grossesse chez 382 femmes de plus de 40 ans : étude rétrospective dans la population de l'île de la Réunion. Gynecol Obstet Biol Reprod 2004; 33: 615-622.
  15. Ziadeh S, Yahaya A. Pregnancy outcome at age 40 and older. Arch Gynecol Obstet 2001; 265: 30-3. 16. Gareen IF, Morgenstern H, Greenland S, Gifford DS. Explaining the association of maternal age with Cesarean delivery for nulliparous and multiparous women. J Clin Epidemiol 2003; 56: 1100-10.
  16. Heffner LJ, Elkin E, Fretts RC. Impact of labor induction, gestational age, and maternal age on cesarean delivery rates. Obstet Gynecol 2003; 102: 287-93.
  17. Ecker JL, Chen KT, Cohen AP, Riley LE, Lieberman ES. Increased risk of cesarean delivery with advancing maternal age: indications and associated factors in nulliparous women. Am J Obstet Gynecol 2001; 185: 883-7.
  18. Jahromi BN, Hussein Z. Pregnancy outcome at maternal age 40 and older .Taiwan J Obstet Gynecol 2008; 47 -3.