Auto immune hepatitis type 1 triggered by cytomegalovirus infection.

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Published Sep 1, 2010
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Vol. 88 No. 9 (2010): Issue Sep 2010

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Leila Mouelhi
Radhouane Debbeche
Mohamed Salem
Slim Bouzaidi
Haifa Mekki
Fatma Houissa
Yosra Said
Amel Moussa
Mejd Ben Rejeb
Sinda Trabelsi
Taoufik Najjar

Abstract

Background : Autoimmune hepatitis is chronic and uncommon disease. The pathogenesis is a complex process. Several triggers for autoimmune hepatitis particularly viral herpesviridea infection, which may induce the development of autoimmunity in predisposed individuals.
Aim : Report a new case.
Case report : We report a case of 17-year- woman presented with autoimmune triggered by cytomegalovirus infection.
Cytomegalovirus induced autoimmune hepatitis has not been reported previously. Evolution was favourable under antiviral treatment, corticosteroid and azathioprine.

Keywords:

Autoimmune hepatitis, herpesviridae

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References

  1. Boberg KM , Aadland E , Jahnsen J, Raknereud N, Stiris M, Bell H. Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population. Scand J Gastroenterol 1998;33: 99-103.
  2. Manns MP, Strassburg C. Autoimmune Hepatitis: Clinical Challenges. Gastroenterology 2001;120:1502-17.
  3. Johnson PJ, McFarlane IG. Meeting report: international autoimmune hepatitis group. Hepatology 1993;18:998-1005.
  4. Cohen JI, Corey GR. Cytomegalovirus infection in the normal host .Medicine (Baltimore) 64 : 100-114, 1985.
  5. Bonnet F, Neau D, Viallard JF, Morlat P, Ragnaud JM, Dupon M. Clinical and laboratory findings of cytomegalovirus infection in 115 hospitalized non-immunocompromised adults. Ann Med Interne (Paris) 2001; 152 : 227-235.
  6. Ishikawa K, Hasegawa K, Naritomi T, Kanai N, Ogawa M, Kato Y et al. Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan . J Gastroenterol 2002 ; 37: 523-530 .
  7. Krawitt ED. Autoimmune Hepatitis . N Engl J Med 2006 ;354:54- 66.
  8. Béland K, Lapierre P, Alvarez F. Influence of genes, sex, age and environment on the onset of autoimmune hepatitis. World J Gastroenterol 2009;15:1025-1034.
  9. Vento S , Guella L , Mirandola F , Cainelli F , Di Perri G , Solbiati M, et al .Epstein-Barr virus as a trigger for autoimmune hepatitis in susceptible individuals. Lancet 1995;346: 608-609.
  10. Kojima K, Nagayama R, Hirama S, Maeda T, Takikawa H, Miyake K, et al . Epstein-Barr virus infection resembling autoimmune hepatitis with lactate deshydrogenase and alkaline phosphatase anomaly. J Gastroenterol 1999 ; 34: 706-712.
  11. Nobili V,Comparcola D, Sartelli MR, Devito R , Marcellini M . Autoimmune hepatitis type 1 after Epstein-Barr virus infection . Pediatr Infect Dis J 2003 ; 22 :387.
  12. [12] Tajiri H, Tanaka-Taya K, Ozaki Y, Okada S, Mushiake S,Yamanishi K. Chronic hepatitis in an infant, in association with human herpesvirus-6 infection . J Pediatr 1997 ; 131:473-475.
  13. Schmitt K, Deutsch J, Tulzer G, Meindi R, Aberle S. Autoimmune hepatitis and adrenal insufficiency in an infant with human herpesvirus-6 infection. Lancet 1996; 348: 966.
  14. Lapierre P, Johanet C, Alvarez F.Characterization of the B cell response of patients with anti-liver cytosol autoantibodies in type 2 autoimmune hepatitis. Eur J Immunol 2003;33:1869-1878.
  15. Manns MP, Griffin KJ, Sullivan KF, Johnson EF. LKM-1 autoantibodies recognize a short linear sequence in P450 IID6, a cytochrome P-450 monooxygenase. J Clin Invest 1991; 88: 1370- 1378.
  16. Waleed K Al-Hamoudi. Severe autoimmune hepatitis triggered by varicella zoster infection. World J Gastroenterol 2009; 28: 1004- 1006.
  17. Heurgué A, Bernard-Chabert B, Picot R , Cadiot G, Thiéfin G. Overlap syndrome triggered by acute viral hepatitis A. Eur J Gastroenterol Hepatol 2009; 11
  18. Tabak F,Ozdemir F, Tabak O,Erer B, Tahan V,Ozaras R. Autoimmune hepatitis induced by the prolonged hepatits A virus infection. Ann Hepatol. 2008;7:177-9.
  19. Matsushita M, Takemura T, Imai Y, Takimoto K, Kuchide M,Kajikawa H et al. A case of probable autoimmune hepatitis from which the persistence of hepatitis A IgM antibody, and the improvement was pathologically obtained by ursodeoxycholic acid medication. Nippon Shokakibyo Gakkai Zasshi 2008; 105:1367-74.
  20. Tanaka H,Tujioka H,Ueda H,Hamagami H, Kida Y, Ichinoise M. Autoimmune hepatitis triggered by acute hepatitis A. World J Gastroenterol 2005;11: 6069-6071.
  21. Munnoz BE, Salazar RV, Robles HF, Correa Estan JA, Belda AG, Munoz Ramirez E. Autoimmune hepatitis caused by acute hepatitis due to hepatitis A virus. Gastroenterol Hepatol 2002;25:501-504.
  22. Tamura T, Suzuki S, Yamato A, Sudo I, Yarada Y, Mochizuki M . A case report of AIH diagnosed by opportunity of hepatitis A infection. Nippon Shokakibyo Gakkai Zasshi 2000; 97: 1043- 1047.
  23. Hilzenrat N, Zilberman D, Klein T, Zur B, Sikuler E. Autoimmune hepatitis in a genetically susceptible patients it triggered by acute viral hepatitis A? Dig Dis Sci 1999;44:1950- 1952.
  24. Oshikata S, Miyanaga O, Kikuchi I, Mihara K, Ishibashi H. A case of autoimmune hepatitis presumably induced by acute hepatitis type A. Acta Hepatol Japonica 1996;37:738-743.
  25. Huppertz HI, Treichel U, Cassel AM, Jeschke R, Meyer KH. Autoimmune hepatitis following hepatitis A virus infection. J Hepatol 1995;23:240-248.
  26. Rahaman SM, Chira P, Koff RS. Idiopathic autoimmune chronic hepatitis triggered by hepatitis A. Am J Gastroenterol 1994;89:106-108.
  27. Vento S, Garofano T, Di Perri G, Dolci L, Concia E, Bassetti D. Identification of hepatitis A virus as a trigger of autoimmune chronic hepatitis type I in susceptible individuals. Lancet 1991;337:1183-1187.
  28. Laskus T, Slusarczyk J. Autoimmune active hepatitis developing after acute type B hepatitis. Dig dis Sci 1989;34:1294-1297.
  29. Chisa M, Keisuke H, Muneko O,Kaori F, Michiari O, Hiroshi . Hepatitis B virus carries status linked to autoimmune hepatitis. Internal Medicine 1996;35:468-471.
  30. Vento S, Cainelli F, Renzini C, Concia E.Autoimmune hepatitis type 2 induced by HCV and persisting after viral clearance. Lancet 1997;350:1298-1299.
  31. Marceau G, Lapierre P, Beland K,Soudeyns H, Alvarez P. LKM1 autoantibodies in chronic hepatitis C infection :a case of molecular mimicry. Hepatology 2005;42:675-682.