Helicobacter Pylori And Gastric Cancer

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Published Jun 18, 2010
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Vol. 88 No. 7 (2010): Issue Jul 2010

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Asma Ouakaa-Kchaou
Service de Gastro-entérologie Hôpital H. Thameur Tunis
Hella Elloumi
Dalila Gargouri
Service de Gastro-entérologie Hôpital H. Thameur Tunis
Jamel Kharrat
Abdeljabbar Ghorbel

Abstract

Background: Patients infected with Helicobacter pylori, a stomach colonizing bacteria, have an increased risk of developing gastric malignancies, in particular gastric carcinomas.
Aim : This review was aimed to analyze the relationship between gastric carcinoma and Helicobacter pylori infection and to rule out the possibility of preventive measures.
Methods: To identify articles for this review, a PubMed search was conducted using the following key words: gastric cancer, Helicobacter pylori.
Results: The risk for developing cancer includes environmental, host-genetic and bacterial factors, which induce physiologic and histologic changes in the stomach. There are two major pathways for the development of gastric cancer by helicobacter pylori: the indirect action on gastric epithelial cells through inflammation leading to gastric atrophy and intestinal metaplasia and the direct action through the induction of protein modulation and gene mutation.

Keywords:

helicobacter pylori, gastric cancer

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References

  1. Prinz C, Schwendy S, Voland P. H pylori and gastric cancer: shifting the global burden. World J Gastroenterol 2005 ; 12:5458-64.
  2. Araujo-Filho I, Brandao-Neto J, Pinheiro L et al. Prevalence of Helicobacter Pylori infection in advanced gastric carcinoma. Arq Gastroenterol 2006;43:288-92.
  3. Tang YL, Gan RL, Dong BH, Jiang RC, Tang RJ. Detection and location of Helicobacter pylori in human gastric carcinomas. World J Gastroenterol 2005;11:1387-91.
  4. Talley NJ, Fock KM, Moayyedi P. Gastric cancer consensus conference recommends Helicobacter pylori screening in asymptomatic persons from high-risk populations to prevent gastric cancer. Am J Gastroenterol 2008;103:510-4.
  5. Chiba T, Marusawa H, Seno H, Watanabe N. Mechanism for gastric cancer development by Helicobacter pylori infection. J Gastroenterol Hepatol 2008;23:1175-81.
  6. Ferreira AC, Isomoto H, Moriyama M, Fujioka T, Machado JC, Yamaoka Y. Helicobacter and gastric malignancies. Helicobacter 2008;13(S1):28-34.
  7. Kim CG, Choi J, Lee JY, Cho SJ, Nam BH, Look MC, Hong EK, Kim YW. Biopsy site for detecting helicobacter pylori infection in patients with gastric cancer. J Gastroenterol Hepatol 2008;13:1-6