Importance of determination of protein C reactive (CRP), antigen carcino embryonnaire (ACE) and lacticodeshydrogenase (LDH) in cancer colorectal

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Published May 21, 2010
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Vol. 88 No. 6 (2010): Issue Jun 2010

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Hajer Abaza
Abderraouf Ghanem
Aouatef Jmal
Hamouda Boussen
Latifa Harzallah
Khaled Rahal
Fethi Guemira

Abstract

Aim : Evaluate and show the importance of CRP, ACE and LDH in colorectal cancer.
Methods: Our prospective study interested 30 patients, from 26 to 93 years old and present a colorectal cancer, confirmed histologically, during the period going from March 2003 to April 2004, and 30 healthy controls. A blood sample was collected from each patient respectively in preoperative, 48 hours before any treatment, and 6 months after surgical operation to measure serum LDH, CRP, and ACE.
Results: The mean serum of LDH, CRP and ACE values were significant higher in patients than those in controls (p respectively: 0,01; 0,04 et 0,01). Moreover, the level of three parameters varied significantly with stages of tumor. After follow up, we have noticed e normalisation of the mean of the level of LDH, CRP and ACE with
favorable evolution. Analysis of survival at 2 years showers that survival is better in patients with normal value of CRP, ACE and LDH.
Conclusion : CRP, LDH and ACE values have a great importance during follows up after colorectal cancer surgery.

Keywords:

Colorectal cancer, lactic deshydrogenase, C reactive protein, antigen carcino embryonnaire, survival

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