Corynebacterium propinquum isolated from a pus collection in a patient with an osteosynthesis of the elbow

##plugins.themes.academic_pro.article.main##

MAbrouka Saïdani
Skander Kammoun
Ilhem Boutiba-Ben Boubaker
Saida Ben Redjeb

Abstract

Background: Although non- diphtherial corynebacteria are ubiquitous in nature and commonly colonize the skin and mucous membranes of humans, they rarely account for clinical infections.
Aim: we report a case of infection due to non- diphtherial corynebacteria, Corynebacterium propinquum.
Case : A Tunisian male patient of 67 years old was admitted to orthopedic surgery and traumatology ward of Charles Nicolle university hospital of Tunis (Tunisia) for a left elbow trauma. He was treated by osteosynthesis and received an antibioprophylactic therapy with amoxicilline-clavulanate and gentamicin association. No postoperative incident was noted. When he was readmitted a month later for the osteosynthesis material removal, clinical examination found a pus collection in the operated elbow. Specimen analysis showed a Gram positive stained bacilli identified as C.propinquum. The organism was resistant only to penicillin G and sulfamethoxazole-trimethoprim association. The patient was treated with ofloxacin (2g per day for 8 days) and gentamicin (160mg per day for 5 days) with clinical improvement.
Conclusion: According to literature, infections due to C.propinquum are rare, occurring especially in patients with medical device or immunocompromised. Thus, this pathogen should be taken in consideration in such situations

Keywords:

Corynebacteria, Corynebacterium propinquum, osteosynthesis, infection

##plugins.themes.academic_pro.article.details##

References

  1. Clinical and Laboratory and Standards Institute , Wayne, Pennsylvania, ISBN 1-56238-556-9, January, 2005 USA
  2. Coyle MB, Hollis DG, Groman NB. Corynebacterium ssp and other coryneform organisms. In: Lenette EH, Balows A, Houster WJ, Shadomy HJ, eds. Manual of clinical microbiology. 4th ed. Washington DC: American Society for Microbiology, 1985: 193-204
  3. Young VM, Meyers WF, Moody MR, Schimpff SC. The emergence of coryneform bacteria as a cause of nosocomial infections in compromised hosts, Am J Med 1981, 70:646-50
  4. K. Lagrou, J. Verhaegen, M. Janssens, G. Wauters, L. Verbist. Prospective Study of Catalase-positive Coryneform Organisms in Clinical Specimens: Identification, Clinical Relevance, and Antibiotic Susceptibility. Diagn Micobiol infect Dis 1998; 30:7-15
  5. Babay.H: Pleural Effusion due to Corynebacterium propinquum in a patient with squamous cell carcinoma. Ann.Saudi.Med 2001;21: 337- 339
  6. Motomura K, Masaki H, Terada M, Onizuka T, Shimogama S, Furumoto A, Asoh N, Watanabe K, Oishi K, Nagatake T.Three adult cases with Corynebacterium propinquum respiratory infections in a community hospital. Kansenshogaku Zasshi. 2004; 78: 277-282
  7. P. Riegel, D. de Briel, G. Prévost, F. Jehl, H. Monteil Proposal of Corynebacterium propinquum sp. nov. for Corynebacterium group ANF-3 strains FEMS Microbiol Lett 1993; 113: 229-234
  8. Lipsky.BA, Goldberger AC, Tomkins.LC: Infections caused by nondiphtheria corynebacteria. Rev Infect Dis 1982;4: 1220-1235
  9. Balci I, Ekfli F, Bayram A. Coryneform bacteria isolated from blood cultures and their antibiotic susceptibilities. J Int Med Res. 2002; 30:422-427.
  10. Babay HA, Kambal AM Isolation of coryneform bacteria from blood cultures of patients at a University Hospital in Saudi Arabia. Ann. Saudi Med J. 2004; 25:1073-9.
  11. Petit. PL, Bok. JW, Thompson. J, Buiting. AG, Coyle. MB. Native valve endocarditis due to CDC Coryneform group ANF-3: report of a case and review of corynebacterial endocarditis. Clin Infec Dis, 1994; 19 :897-901
  12. Chudnicka A, Koziol-Montewka M. Characteristics of opportunistic species of the Corynebacterium and related coryneforms isolated from different clinical materials. Ann univ Mariae Curie Sklodowska, 2003; 58:385-391
  13. Camello TCF, Mattos-Guaraldi AL, Duarte Formiga LC, Andrade Marques E. Nondiphtherial Corynebacterium species isolated from clinical specimens of patients in a university hospital, Rio De Janeiro, Brazil. Braz. J. Microbiol 2003; 34:39-44
  14. Roux. V, Drancourt. M, Stein. A, Riegel.P, Raoult. D, La Scola. B, Corynebacterium Species Isolated from Bone and Joint Infections Identified by 16S rRNA Gene Sequence Analysis. J. Clin Microbiol. 2004; 42:2231-2233