A Rare Cause of Pruritis in an Haemodialysed Patient

##plugins.themes.academic_pro.article.main##

Soumaya Béji
Lilia Ben Fatma
Lamia Rais
Karim Zouaghi
Mediha Krid
Wided Smaoui
H Ben Maiz
Fatma Ben Moussa

Abstract

Background : Uremic pruritus is frequent in patients undergoing hemodialysis. It’s multifactorial secondary in most cases to metabolic complications related to uremia.
Aim : We report a rare cause of pruritis in an haemodialysed patient
Observation : It’s a 48-year-old woman in periodic haemodialysis during 17 years. She suffered from generalized pruritus associated with psychiatric disturbance without neurologic deficits. CT scan and magnetic resonance imaging revealed extensive, diffuse and bilateral involvement of the white matter. The diagnosis of large low grade B cell lymphoma was confirmed by the histologic examination of stereotactic biopsy which leads to early intracranial hemorrhage and death.
Conclusion: Before attributing pruritus to renal failure, one should exclude other causes such as the NHL even rarely reported especially when it associated with psychiatric disturbances. CT scan and magnetic resonance imaging contribuate to diagnosis.

Keywords:

Pruritis, cerebral lymphoma, haemodialysis

##plugins.themes.academic_pro.article.details##

References

  1. Burn DJ, Bates D. Neurology and the kidney. J Neurol Neurosurg Psychiatry 1998; 65:810-21.
  2. Brouns R, De Deyn PP. Neurological complications in renal failure: a review. Clin Neurol Neurosurg 2004; 107:1-16
  3. Fossati S, Boneschi V, Ferrucci S, Brambilla L. Human immunodeficiency virus negative Kaposi sarcoma and lymphoproliferative disorders. Cancer 1999 ;85 :1611-5.
  4. De Toledo M, López-Valdés E, Ferreiro M and al. Lymphomatosis cerebri as the cause of leukoencephalopathy. Rev Neurol 2008; 46:667-70.
  5. Kumar SS, Kuruvilla M, Pai GS, Dinesh M. Cutaneous manifestations of nonhodgkin's lymphoma. Indian J Dermatol Venereol Leprol 2003 ; 69 : 12-5
  6. Narita I, Iguchi S, Omori K, Gejyo F. Uremic pruritus in chronic hemodialysis patients. J Nephrol 2008; 21: 161-5.
  7. Mettang T, Pauli Magnus C, Alsher DM. Uraemic pruritus: New perspectives and insights from recent trials. Nephrol Dial Transplant 2002; 17: 1558-63.
  8. Daponte A, Ioannou M, Gioti C, Kallitsaris A, Dalekos GN, Messinis IE. Primary retroperitoneal non-Hodgkin lymphoma presenting with torturous generalized pruritus in an elderly. Arch Gynecol Obstet 2007; 275: 287-9.
  9. Ozgiray E, Oner K, Ovul I. HIV related toxoplasmic encephalitis mimicking multiple metastasis: case report. Turk Neurosurg 2007;17:207-10.
  10. Pepion C, Jacob L, Samama CM. Insuffisance rénale chronique et syndrome hémorragique. Sang Thrombose Vaisseaux 2003;15:442-8.
  11. Kiewe P, Fischer L, Martus P, Thiel E, Korfel A. Primary central nervous system lymphoma: monocenter, long-term, intent-to-treat analysis. Cancer 2008; 112: 1812-20
  12. Doolittle ND, Abrey LE, Shenkier TN and al . Brain parenchyma involvement as isolated central nervous system relapse of systemic non- Hodgkin lymphoma: an International Primary CNS Lymphoma Collaborative Group report. Blood 2008; 111: 1085-93.
  13. Feldmann G, Nattermann J, Gerhardt T, Nähle CP, Spengler U, Woitas R. Partial remission of a newly diagnosed diffuse large B-cell Non-Hodgkin's lymphoma in a hemodialysis patient after administration of immunochemotherapy with rituximab-CHOP. Int J Lab Hematol 2007;29: 469-73.