Tumors of salivary glands: anatomical study and clinical epidemiology of a series of 180 cases

##plugins.themes.academic_pro.article.sidebar##

Published Apr 2, 2010
Download
pdf
Vol. 88 No. 4 (2010): Issue Apr 2010

##plugins.themes.academic_pro.article.main##

Ehsen Ben Brahim
Malek Ferchiou
Olfa Khayat
Sarra Zribi
Naceur Labbène
Abdelkader El Khedim
Mohamed Ben Ayed
Achraf Chadli-Debbiche

Abstract

Background: The salivary gland tumors are rare (less than 3% of all tumors) and poorly known. In fact, they are numerous and histologically difficult to diagnose.
Aim : This work aims to point at the different histological types of salivary gland tumors, to draw out the principal epidemiological, clinical, radiological and histological characteristics, and to compare our cases to those of the literature.
Methods:Accordingly, we performed a descriptive type study about 180 cases of salivary gland tumors from the departments of
pathology and oto-rhino-laryngology of Habib Thameur hospital during 25 years, extending from April 1979 to December 2004.
Results: Benign tumors were predominant (88%), while malignant ones represented 12% of our cases dominated by carcinomas. The sex-ratio was 0.96. Parotid gland location was the most frequent one, and pleomorphic adenoma was the most frequent tumor (62%).
Conclusion: Histological diversity of salivary tumors results in difficulties for differential diagnosis. These problems can be solved by a precise diagnostic approach and sometimes by an immunohistochemistry study.

Keywords:

Salivary gland tumors, Parotid gland, Submandibular gland, Accessory salivary gland

##plugins.themes.academic_pro.article.details##

References

  1. Bonfils P. Tumeurs des glandes salivaires. Encycl. Méd. Chir. (Paris-France), Oto-Rhino-Laryngologie 20-628-B-10,206, 18p.
  2. Van der Wal JE, Leverstein H, Snow GB, Kraaijenhagen HA, Van der Wal I. Parotid gland tumors: histologic reevaluation and reclassification of 478 cases. Head Neck 1998;20:204-7.
  3. Hamoir M, Desuter G, Hamoir X, Duprez Th, Gréoire V. Pathologies malignes de la loge sous-mandibulaire. Les cahiers d'ORL 1995;5:301-8.
  4. Da Cruz Perez DE, Pires FR, Alves FA, Almeida OP, Kowalski LP. Salivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of 53 cases. Int J Pediatr Ototlaryngol 2004;68:895-902.
  5. Therkildsen MH, Christensen M, Andersen LJ, Schiodt T, Hansen HS. Salivary gland carcinomas. Acta Oncologica 1998;37:701-13.
  6. Brocheriou C, Crepy C, Guilbert F, Lartigau G, Payen J, Recoing J. Tumeurs des glandes salivaires accessoires de la cavité buccale. Etude de 296 cas. Bull Cancer 1980;67 :29-37.
  7. Barnes L, Everson JW, Reichart P, Sidransky D. World Health Organisation Classification of Tumors. Pathology and Genetics of Head and Neck Tumors. IARC Press: Lyon 2005.
  8. Costes V. Tumeurs des glandes salivaires. Ann Pathol 2007;27 :1S69-80.
  9. Chevalier D, Loche V, Darras J, Apko-Allavo J, Desaulty A, Piquet J. Les reprises et récidives d'adénome pléomorphe de la glande parotide. A propos de 62 cas. Ann Otolaryngol Chir Cervicofac 1996;133 :56-60.
  10. Laskawi R, Rachdi A, Ellies M, Brauneis J. le cystadénolymphome : étude clinique et thérapeutique. Les cahiers d'ORL 1994 ;4 :44-50.
  11. Saku T, Hayashi Y, Takahara O et all. Salivary gland tumors among atomic bomb survivors, 1950-1987. Cancer 1997;79:1465-75.
  12. Maiorano E, Altini M, Favia GF. Clear cell tumors of the salivary glands, jaw and oral mucosa. Semin Diagn Pathol 1997;14:203-12.
  13. Wahlberg P Anderson H, BiorkLund A, Moller T, Perfect R. Carcinoma of the parotid and submandibular glands. A study of survival in 2465 patients. Oral Oncol 2002;38:706-13.
  14. Hicks MJ, El-Naggar AK, Flaitz CM, Luna MA, Batsakis JG. Histologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival: a clnicopathologic and flow cymetric investigation. Head Neck 1995;17:8995.
  15. Spiro RH, Huvos AG, Strong EW. Adenoid cystic carcinoma: factors influencing survival. Am J Surg 1979;138:579-83.
  16. Strick MJ, Kelly C, Soames JV, McLean NR. Malignant tumors of the minor salivary glands. A 20 years review. Br J Plast Surg 2004;57:624-31.
  17. Perez-Ordonez B. Selected topics in salivary gland tumor pathology. Curr Diagn Pathol 2003;9:355-65.
  18. Seifert G, Oehne H, Mesenchymal (Non-epithelial) salivary gland tumors. Analysis of 167 cases of the salivary gland register. Laryngol Rhinol Otol 1986;65:485-91.