Clinicals and biologicals aspects of ICSI cycles on Polycystics Ovary syndrome patients.

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Published Mar 1, 2010
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Vol. 88 No. 3 (2010): Issue Mar 2010

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Mohamed Khrouf
Moez Kdous
Maha Bouyahia
Anis Chaker
fathi Zhioua
Amel Zhioua

Abstract

Aim :To analyse clinicals et biologicals pecularities of Polycystics Ovarian Syndrome(PCOS) patients enrolled on ICSI cycles and compare them to normo-ovulatory women.
Methodes : 100 controlled ovarian stimulation cycles for ICSI in women with PCOS and 200 cycles in normo-ovulatory women.
Results: There was no significant difference in term of cancellation rate (5,5% in PCOS group vs 5%;NS) . The mean number of follicles was higher in patients with PCOS (18,1 ± 8,5 vs 9,4± 5,5; p <0,05), Oocyte mature rate and fertilization rate were higher in PCOS group (67% vs 52%; p<0,05) (75% vs 63,7%; p<0,05) respectively. Grade 1 Embryo rate was significantly higher in PCOS group (69% vs 53%; p<0,05). Implantation rate (16,6% vs 12,1%; NS) and clinical pregnancy rate per transfer (31,5% vs 22,2%; NS) did not differ statistically in the two groups. Miscarriage rate was higher in PCOS group but this did not reach the statistical significance (20% vs 7,1%; NS). 11 cases of Ovarian hyperstimulation syndrome occurred in PCOS group versus 4 on normo-ovulatory group.
Conclusion: Use of ICSI as fertilization technique was correlated with good biologic parameters on PCOS patients with better fertilization rate and embryo quality and similar pregnancy rate comparing to normo-ovulatory women. However, it still be great concern about high risk of miscarriages and Hyperstimulation ovarian syndrome.

Keywords:

Polycystics Ovarian Syndrome, ICSI cycles

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