Efficacy and safety of statins in the treatment of diabetic dyslipidemia

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Olfa Berriche
Chiraz Amrouche
Henda Jamoussi
Samira Blouza

Abstract

Background: The Adult Treatment Panel III recommends 3- hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or statins as first-line-lipid-altering therapy for all adult patients with diabetes mellitus. This is based on the well-characterized efficacy and safety profiles of this class of agents as well as several clinical trials
demonstrating that statin treatment reduces the risk of cardiovascular events.
Aim : The objective of our study was to investigate the efficacy and safety of statin therapy in patients with diabetes type 2.
Methods: We analyzed data from 120 individuals with diabetes type 2. For all patients, the mean baseline LDL-cholesterol level was 4,26±0,82 mmol per liter, the total cholesterol level was 6,52±0,75 mmol/l, HDL-cholesterol level was 1,15±0,31 mmol/l and triglyceride level was 1,77±0,67 mmol/l.
Results: There was a significant reduction in total cholesterol (P = 2.10-3) and LDL-cholesterol (P = 5.10-4) with statins; the mean LDL-cholesterol level was reduced from 4,26±0,82 mmol/l at baseline to 2,8±0,59 mmol/l at 12 months. The percentage variation of LDL-cholesterol was between 24 and 35%; in addition, the percentage reduction of total cholesterol was between 22 and 28%, the mean reduction in TG levels was between 11 and 16%.There was a no significant increasing in HDL cholesterol. Among these 120 patients, 5,1% had a moderate CK elevation. Moreover 2% had a significant elevation of transaminase levels. Statins have also been associated with muscle-related adverse events; so milder complaints (myalgia) are reported by approximately 3,6% of patients who take statins.
Conclusion: Statins as highly efficacious agents for the lowering of low-density lipoprotein-cholesterol (LDL-C) revolutionized treatment of hypercholesterolemia, a long established risk factor for premature coronary heart disease and they are not only exhibit a remarkely high benefit to risk ration, but are equally characterized by a safety profile with excellent tolerance.

Keywords:

Statins, LDL-Cholestero, Total cholesterol, Triglycerides, Creatine kinase, Transaminases

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