Pulmonary metastases revealing choriocarcinoma

##plugins.themes.academic_pro.article.main##

Leila El Fekih
Hela Hassene
Soraya Fenniche
Hajer Ben Abdelghaffar
Dalenda Belhabib
Mohamed Lamine Megdiche

Abstract

Background: Uterin choriocarcinoma is a trophoblastic tumour characterised by high metastasis potential. Pleuropulmonary metastasis can reveal rarely the neoplasm.
Aim : Repport a new case.
Case report: We report the case of a 31 years- old woman, with no pathological antecedent, admitted in our department for thoracic pain and haemoptysis occurring two months after delivery of a did in child-birth. Chest X ray and thoracic CT scan showed several bilateral opacities.
 A diagnosis of metastatic choriocarcinoma was confirmed by plasmatic level of ß human chorionic gonadotrophin (ß HCG) superior to 4000 UI/ml. Gynaecological exam revealed latero-uterine mass. Abdomino-pelvien ultra sound and CT scan showed tissular latero uterine and hepatic masses. Brain CT scan had been normal.
Patient did after 3 cures of chemotherapy because of acute respiratory failure caused by massive pulmonary embolism.
Conclusion: Diagnosis of choriocarcinoma must be evocated in front of several pulmonary opacities occurring in genital activity women and necessities the dosage of level of ßHCG.

Keywords:

Choriocarcinoma, Lung, Metastasis, Chemotherapy

##plugins.themes.academic_pro.article.details##

References

  1. Malbran CHE, Aupecle M.H, Chaboche Ch, Theodore Ch. Choriocarcinome materno-f?tal après accouchement normal :J Gyn Obst Biol Reprod.1993;33:789-792.
  2. Chang WC, Hung YC, Shen HP. Choriocarcinoma with pulmonary metastasis J. Reprod Med. 2007 ; 52 : 450-23
  3. Fatnassi R, Slimène F, Dhouibi S, Karray T, Nagra R. Choriocarcinome utérin révélé par des métastases pulmonaires. La Tunisie Médicale. 2005 : 645-647
  4. Guerin IC, Touraine R, Biron P, Pasquier J. Métastases pulmonaires révélatrices d'un chorio carcinome placentaire. Rev Mal Resp. 1986; 4: 401-6.
  5. Libshitz HT,Baber CE,Hammond CB,FOCOGM D. The pulmonary metastasis of choriocarcinoma.Obstet gynecol 1997, 412-415.
  6. Philippe E, Boue J, Boue A. Les maladies trophoblastiques gestationnelles. Ann Anat Path 1980; 1:13-38.
  7. Maigre M, Thomas B, Camp G, Theodore CH. Choriocarcinome uterin révélé par des métastases pulmonaires. Sem Hop (Paris) 1992; 68,: 1408-1411.
  8. Droz JP, Lhomme C.Les tumeurs trophoblastiques gestationnelles. Rev Prat 1992; 42:7.
  9. Golfier F,Raudrant T,Frappar JL et all .Les moles hydatiformes et les tumeurs trophoblastiques :Conduite à tenir pratique :mise à jour en gynecologie et obstetrique :VIGOT 2003 : 53-100.