VENOUS INVOLVEMENT IN BEHCET’S DISEASE : A SERIES OF 28 CASES

##plugins.themes.academic_pro.article.sidebar##

Published Dec 9, 2009
Download
pdf
Vol. 87 No. 12 (2009): Issue Dec 2009

##plugins.themes.academic_pro.article.main##

Sonia Ketari Jamoussi
Hatem Chaaba
Besma Ben Dhaou
Samir Kochbati
Fatma Boussema
Ouahida Cherif
Lilia Rokbani

Abstract

Background: Venous involvement is a rare and severe clinical feature in Behcet disease (BD).
Aim : We reported our experience with a rare and interesting subset of BD patients with venous involvement. Methods: From 1994 to 2008, twenty eight cases of venous BD were found amongst BD patients in the department of internal medicine of Habib Thameur Hospital.
Results: 45 episodes of venous thrombosis occurred in 28 patients. There were 25 men and 3 women the mean age when venous involvement manifested was diagnosed was about 32.25. Venous thrombosis occur in the first five years following the diagnosis of BD. Pericarditis was more frequently noted in patients with venous BD than others without vasculo-Behcet disease. In contrast digestive and rheumatologic symptoms were more likely observed in patients without vasculo-Behcet disease. Thirteen patients underwent corticosteroids. Relapses occurred more frequently in patients without corticosteroid therapy.
Conclusion: Venous involvement is more frequently noted in vasculo-Behcet than arterial involvement. Its treatment should include anticoagulation in association with corticosteroids.

Keywords:

Behcet disease, Venous involvement, corticosteroid therapy

##plugins.themes.academic_pro.article.details##

References

  1. Koç Y, Gullu I, Akpek G et al. Vascular involvement in Behcet's disease. ] Rheumatol 1992; 19: 402-410.
  2. Le Thi Huong D, Wechsler B, Papo T et al. Arterial lesions in Behçet's disease. A study in 25 patients.J Rheumatol 1995;22:2103-13
  3. Houman Mh, Ben Ghorbel I, Khiari Ben Salah I , Lamloum M, Ben Ahmed M, Miled M. Deep vein thrombosis in Behçet's disease. Clin Exp Rheumatol 2001;19(5 Suppl 24):S48-50.
  4. Tazi Mezalek Z, Sahnoune I, Essalmi L et al. Deep vein thrombosis in Behçet's disease in Moroccan patients. In: Yazici H, Direskeneli H, Hamurydan V, Melikoglu M, Ozdogan H, Yavuz S, editors. 11th International Congress on Behçet's disease. Book of abstracts. Antalya. 2004 (S-109)
  5. Ko Gy, Byun Jy, Choi Bg, Cho SH. The vascular manifestations of Behçet's disease: angiographic and CT findings. Br J Radiology 2007;3:1270-74.
  6. Kabbaj N, Ben Jelloun G, Gueddari Fz, Dafiri R, Imani F. Les atteintes vasculaires de la maladie de Behçet- A propos de 40 dossiers. J Radiol 1993; 14: 107S
  7. Tohmé A, Aoun N, El-Rassi B, Ghayad E. Vascular manifestations of Behçet's disease: 18 cases among 140 patients. Rev Rhum. 2003; 70: 766-772.
  8. Sarica-Kucukoglu, Akdag-Kose A, Kayabali M et al. Vascular involvement in Behçet's disease: a retrospective analysis of 2319 cases. Int J Dermatol. 2006; 45: 919-21
  9. Sagdic K, Ozer Zg, Saba D, Ture M, Cengiz M. Venous lesions in Behçet's disease. Eur J Vasc Endovasc Surg 1996;11:437-440.
  10. Rigby As, Chemberlain Ma, Bhakta B. Behçet's disease. Baillière's Clin Rheumatol 1995;9:375-395.
  11. Alpsoy E, Zouboulis Cc, Ehrlich GE. Mucocutaneous lesions of Behçet's disease 2007;48:573-585.
  12. Hamzaoui B'chir S, Harmal A, Bouslama K ET AL. La maladie de Behçet en Tunisie. Etude clinique de 519 cas. Rev Med interne 2006 ;22 ;742-750.
  13. Houman Mh, Ben Ghorbel I, Khiari Ben Salah I ET AL. Deep vein thrombosis in Behçet's disease. Clin Exp Rheumatol 2001;19(5 Suppl 24):S48-50.
  14. Houman Mh, Neffati H, Braham A et al. Behçet's disease in Tunisia. Demographic, clinical and genetic aspects in 260 patients. Clin Exp Rheumatol. 2007; 25 (4 Suppl 45): S58-64.
  15. Wechsler B, Piette Jc, Conard J, Le Thi Huong D, Bletry O, Godeau P. Les thromboses veineuses profondes dans la maladie de Behçet. 106 localisations sur une série de 177 malades. Presse Med 1987;16:661-4
  16. Benamour S, Chaoui L, Zeroual B et al. Study of 673 cases of Behçet's disease. In: Oliveri I, Salvarani C, Cantini F, editors. 8th International Congress on Behçet's disease. Program and abstracts. Milano: Prex; 1998. p. 232.
  17. Nakae K, Masaki F, Hashimoto T, Inaba G, Mochizuki M, Sakane T. Recent epidemiological features of Behçet's disease in Japan. In: Wechsler B, Godeau P, editors. Behçet's disease. Amsterdam: Excerpta Medica; 1993. p. 145-51.
  18. Gurler A, Boyvat A, Tursen U. Clinical manifestations of Behçet's disease: an analysis of 2147 patients. Yonsei Med J 1997;38:423-7.
  19. Suh Ch, Park Yb, Song J, Lee Ch, Lee SK. Oligoclonal B lymphocyte expansion in the synovium of a patient with Behcet's disease. Arthritis Rheum 2001;44:1707-12.
  20. Zouboulis Cc, Kotter I, Djawari D et al. Adamantiades-Behçet's disease: Epidemiology in Germany and in Europe. In: Lee S, Bang D, Lee E-S, Sohn S, editors. Behçet's Disease. A Guide ti its clinical Understanding. Textbook and Atlas. Berlin, Heidelberg: Springer; 2001: p. 157-69.
  21. Turki S, Ben Taarit C, Ghaddoum H, Ben Fatma L, El Younsi F, Ben Maïz H. Les thromboses veineuses aucours de la maladie de Behçet: Ã propos de 169 cas localisations chez 71 patients. Rev Med Int 2001;22 (Suppl1):76S.
  22. Hamza M. Maladie de Behçet. 4th ed. In: Kahn MF, Peltier AP, Meyer O, Piette JC,editors. Maladies et syndromes systémiques. Paris: Flammarion Médecine-Sciences; 2000: 883-924.
  23. Domiroglu H, Barista I, Dundar S. Risk factor assessment and prognosis eye involvement in Behçet's disease in Turkey. Ophtalmology 1997;104:701-5.
  24. Kuzu Ma, Ozaslan C, Koksoy C, Gutler A, Tuzuner A. Vascular involvement in Behçet's disease: 8-years audit.World J Surg 1994;18: 948-53.
  25. Hamza M. Large artery involvement in Behçet's disease. J Rheumatol 1987; 14: 554-9.
  26. Orloff La, Orloff MJ. Budd-Chiari syndrome caused by Behçet's disease: treatment by side to side portocaval shunt. J Am Coll Surg 1999;188:701-5.
  27. Evereklioglu C. Managing the symptoms of Behçet's disease. Exp Opin PHARMACOTHER 2007;5:317-28.
  28. Houman Mh, Smiti-Khanfir M, Hamzaoui K. Traitements actuels et perspectives thérapeutiques dans la maladie de Behçet. Press Med 2008;37:25-35.