SOLUBLE TRANFERRIN RECEPTOR IN THE BIOLOGICAL DIAGNOSIS OF IRON DEFICIENCY. ABOUT 24 CASES.

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Published Dec 9, 2009
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Vol. 87 No. 12 (2009): Issue Dec 2009

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Mohamed M Zorgati
Raouf Hafsia
Afef Bahlous
Sonia Bahri
Slim Ben Ammar

Abstract

Background: In inflammatory diseases, classical parameters of iron status (serum iron, serum ferritin, total iron-binding capacity of transferrin and transferrin saturation) are not very reliable.
Aim: The purpose of this study is to investigate soluble transferrin receptor, its index and classical parameters of iron status [serum iron, serum ferritin, total iron-binding capacity of transferrin and transferrin saturation] during iron-deficiency anemia and combined iron deficiency and inflammatory anemia.
Methods: Our study concerned 24 patients: 18 patients with irondeficiency anemia and 6 patients with combined iron-deficiency and inflammatory anemia. 55 healthy subjects were included as controls. Both groups underwent classical parameters of iron status [serum iron, serum ferritin, total iron-binding capacity of transferrin and transferrin saturation] and measurement of soluble transferrin receptor with its index.
Results: In iron-deficiency anemia, total iron-binding capacity of transferrin, soluble transferrin receptor and its index were enhanced, whereas serum iron, ferritinemia and transferrin saturation were low compared to controls. Compared to patients with iron-deficiency anemia, those with combined iron-deficiency and inflammatory anemia showed higher levels of serum iron and ferritinemia. In contrast, soluble transferrin receptor and its index did not vary significantly between both groups.
Conclusion: Our findings show the interest of soluble transferrin receptor and its index in the detection of iron deficiency during anemia of inflammatory states.

Keywords:

Iron-deficiency anemia, iron, ferritin, transferrin receptors, inflammation

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