EFFECTS OF RISEDRONATE ON BONE TURNOVER MARKERS IN OSTEOPOROTIC POSTMENOPAUSAL WOMEN: COMPARISON OF TWO PROTOCOLS OF TREATMENT.

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Published Dec 2, 2009
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Vol. 87 No. 8 (2009): Issue Aug 2009

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Afef Bahlous
Kahena Bouzid
Héla Sahli
Slaheddine Sallami
Jaouidia Abdelmoula

Abstract

Background: Bisphosphonates are powerful agents able to prevent bone loss.
Aim: The objective of the study was to evaluate the efficacy and tolerability of risedronate once a week (35 mg) compared with risedronate 5 mg once daily in women with osteoporosis.
Methods: A randomized, double-blind, active-controlled study enrolled 102 postmenopausal women aged 66.5+7.5 years with osteoporotic fractures. All women received risedronate during 6 months. Group 1 (G1, n=51) received risedronate 5 mg once daily and group 2 (G2, n=51) received 35 mg once a week. Serum alkaline
phosphatase (ALP), bone alkaline phosphatase (bone ALP), serum C-terminal telopeptide of type I collagen (CTX) were measured at baseline, 3 months and 6 months after treatment in the two groups.
Results: We noted no significant difference in markers between women of the 2 groups. After 3 months, bone ALP and CTX decreased (respectively -22.1% and -47.6%) in the 2 groups with no significant difference between them. After 6 months study, bone ALP and CTX decreased respectively by -46.5% and -62.9% with no statistically significant difference between study groups for bone markers.
Conclusion: Our study found that treatment with once weekly risedronate 35 mg is able to decrease CTX and bone ALP compared with risedronate 5 mg once daily, in postmenopausal women with osteoporotic fractures. We didn’t find adverse events with the 35 mg once-a-week dose group compared to the once-daily dose group.
Based on these results, the effects of risedronate 35 mg once a week are similar in efficacy to daily dosing and may lead less adverse events than once-a-month dose. This therapeutic protocol may provide an alternative for patients who prefer once-a-week oral dosing.

Keywords:

Risedronate, bone markers, menopause, osteoporosis, fracture

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