Amal Baccar
Besma Yacoubi Loueslati
Wafa Troudi
Slama Hmida
Amel Dridi
Afef Jridi
Karima Mrad
Khaled Ben Romdhane
Amel Ben Ammar Elgaaied


Background: Tumor cells express surface structures different from normal cells. These structures may be recognized by the immune system, which ensure anti-tumoral surveillance. Antigenic presentation requires HLA molecules role. Since, these molecules are encoded by a high polymorphic system, immune response can be modulated according to HLA genotype. So, HLA polymorphism could be correlated with tumor escape from anti-tumor immunosurveillance.
Aim : We have aimed to search for possible associations between HLA DQB1 alleles and the histoprognostical parameters in breast cancer in the Tunisian population.
Methods: DQB1 alleles were determined by PCR-SSO molecular typing in 100 healthy matched and unrelated Tunisian female and 87 Tunisian women with breast cancer.
Results: Allelic distribution between the two studied groups showed no significant associations between this locus and the occurrence, the EE grade and the lymph node invasion of breast cancer in the Tunisian population.
Conclusion: This result may be explained by the fact that cancer is a multifactoral disease due to several interacting factors that might change from one population to another.


DQB1, breast cancer, histoprognostical parameters



  1. Bloom Hjg, Richardson Ww. Histological grading and prognosis in breast cancer: study of 1409 cases of which 539 have been followed for 15 years. British Journal of Cancer 1957; 11: 359-377
  2. Elston Cw, Ellis Io. Pathological prognosis factors in breast cancer.I. The value of histological grade in breast cancer : experience from a large study with long-term follow-up. Histopathology 1991; 19: 403-410.
  3. Dunn Gp, Old Lj, Schreiber RD.The Immunobiology of Cancer Immunosurveillance and Immunoediting. Immunity 2004; 21: 137-148
  4. Chaudhuri S, Cariappa A, Tang M, et al. Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles. P.N.A.S. 2000; 97 : 11451-11454.
  5. Ghaderi A, Talei A, Gharesi-Fard B, Farjadian Sh, Amirzagar A , Vasei M. HLA-DRB1 alleles and the susceptibility of Iranian patients with Breast cancer. Pathology Oncology Research 2001;1: 39-4.
  6. Baccar H A, Yacoubi Lb, Troudi W et al. HLA Class II Polymorphism: Protective or risk factors to breast cancer in Tunisia? Pathology and Oncology Research 2006; 12:79-81.
  7. Khodjet El Khil H, Triki Mr, Yacoubi Lb, Langaney A, Benammar E A.Y chromosome microsatellite variation in three populations of Jerba Island (Tunisia). Annals of Human Genetics 2001; 65: 263-270.
  8. Yacoubi Lb, Ennafaa H, Khodjet El Khil H et al. Human mitochondrial DNA types in two different ethnic groups of Jerba. Biologia Tunisie 2004; 2: 40-48.
  9. Yacoubi Lb, Cherni L, Khodjet El Khil H et al. Islands inside an Island: Reproductive Isolates on Jerba Island. American Journal of Human Biology 2006; 18: 149-153.
  10. Hmida S, Gauthier A, Dridi A, et al. HLA class II polymorphism in Tunisians. Tissue Antigens 19995; 45: 63-68.