VARIATION OF C TROPONIN T IN CHRONIC HEMODIALYSIS PATIENTS: STUDY ABOUT 52 CASES.

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Vol. 87 No. 4 (2009): Issue Apr 2009

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Mnif O
Belhadj R
Zerelli L
Helal I
El Younsi F
Abdelmoula J
Khedher A

Abstract

Background : Patients with severe renal dysfunction have unexplained elevated serum concentrations of cardiac troponin T.
Aim : study the frequency of elevated cTnT in hemodialysis patients and investigated whether cTnT is elevated.
Methods : the patient population consisted of 52 patients on maintenance hemodialysis and 20 healthy subjects. cTnT was measured before and after hemodialysis by using immunoenzymatic method. cTnT were undetectable in 7 cases(<0.01ng/ml) and higher than normal range(up to 0.1ng/ml) in 9 cases. 32 cases have a level of cTnT >0.01 and <0.1ng/ml. In addition, TnTc levels are significantly associated with cardiac dysfunction (p<0.05) and inflammation (p0.01).
Résultats : After hemodialysis sessions, TnTc was less than 0.01 ng / l in 11 patients (21.2%), between 0.01 and 0.1 ng / ml in 32 subjects (61.5%) and greater than 0.1 ng / ml in 9 subjects (17.3%). In the control group, only 1 subject (5%) had a rate of TnTc between 0.01 and 0.1 ng / ml, whereas it was less than 0.01 ng / ml for all others. We aim a statistically significant positive correlation between the rate of TnTc and heart failure (p <0.05) on the one hand and serum CRP (p <0.01) on the other.
Conclusion : The causes of elevated cTnT levels in hemodialysis patients was multiple: cardiac dysfunction, left ventricular dysfunction and inflammation.

Keywords:

Troponin T, hemodialysis, chronic renal failure

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