HISTOLOGICAL FEATURES OF CELIAC DISEASE IN SOUTH TUNISIA: A STUDY OF 114 PAEDIATRIC CASES

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Vol. 87 No. 4 (2009): Issue Apr 2009

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Rim Kallel
Saloua Krichen-Makni
Sameh Ellouze
Chiraz Châari
Slim Charfi
Ahmed Sellami
Mohamed-Nabil Tahri
Mongia Hachicha
Service de pédiatrie Générale CHU H Chaker Sfax Tunisie
Tahya Sellami-Boudawara
Laboratoire d'Anatomie et de CytologiePathologiques CHU. Habib Bourguiba Sfax-Tunisie

Abstract

Aim: to report the histological features of celiac disease in a paediatric population originating from south Tunisia.
Methods:Aretrospective study of a series of duodenal biopsies from 114 children with celiac disease diagnosed over a period of 6 years (from January 1999 to December 2004). The diagnosis was confirmed by histological results, serological studies and clinical response to gluten free diet.
Results: the average age of patients was of 6.2 years (range 6 months-15 years). Sex ratio was 0.71. Symptoms were dominated by chronic diarrhea (48%), weight loss (50%) and anemia (20.1%). Histological findings showed an intraepithelial lymphocytosis (Marsh type 1) in 12.2 % of cases, type 2 was present in 1.7 % of cases and type 3 (villous atrophy) in 86% of cases. A treatment with a gluten-free diet was indicated for all patients, only the cases who haven’t presented a clinical amelioration (11 cases) have beneficed a control biopsie; a villous atrophy was persistent in 80% of this patients.
Conclusion: Histological features in duodenal biopsies for the diagnosis and the follow-up of patients with coeliac disease. This allows an appropriate treatment and prevents further complications.

Keywords:

biopsy, coeliac disease, villous atrophy, child, gluten free diet

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