PRIMARY BREAST LYMPHOMA: A case report
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Abstract
Background : Non-hodgkinian's lymphoma (NHL) represents 0. 04 to 0. 53% of all breast cancers. The clinical aspects and therapeutic models of the disease are a subject of debate.
Aim : The purpose of this paper is to report the clinical, imaging (sonographic, mammographic and MRI) and pathological features of breast lymphoma, a rare but aggressive tumor, based on a case report review.
Case report: We report a case of primary non-hodgkinian's lymphoma of the breast in one patient aged of 52 years. The patient weart to a systematic screening of breast cancer. Physical examen was normal. Mammography showed breast with transitional density, BIRADS type 2, micro-calcifications behin the .... but sometimes it had linear ...., neither not distorsion were identified. Ultrasonography did not show a tumor. The disease was revealed by breast MRI. The additional value of MRI in diagnosis is validated in our patient. In fact,when cancer is occult, size evaluation is difficult at standard imaging (7mm). The diagnosis of non-hodgkinian's lymphoma was confirmed on histological examination of tumor biopsies. It was a Bcell non-Hodgkins-type lymphoma. The clinical features have been reviewed and the tumor have been evaluated both on a morphologic and an immunohistochemical basis. With chemotherapy, the course was favourable.
Conclusion: The breast is an uncommon site of development of malignant lymphomas. Secondary disease is more common than the primitive form. Primary breast lymphoma is a difficult diagnosis because it is very rare. The diagnosis is mainly histological. Chemotherapy is the principal therapeutic mean. Treatment combines radiotherapy and chemotherapy. Prognosis is generally bad.
Keywords:
Lymphoma, Breast, Cancer##plugins.themes.academic_pro.article.details##
References
- Virginia E, Vishnu V.B, Nirag C, David C, Darshana N. Non- Hodgkin's lymphoma of the breast: a review of 18 primary and secondary cases. Annals of Diagnostic Pathology 2006;10:144-148
- R. Fatnassi and I. Bellara Primary non-hodgkinian's lymphomas of the breast: report of two cases. J Gynecol Obstet Biol Reprod 2005 ;34 : 721-24 .
- Arber DA, Simpson JF, Weiss LM, Rappaport H. Non-Hodgkin's lymphoma involving the breast. Am J Surg Pathol 1994;18 : 288-95.
- Hugh JC, Jackson FI, Hanson J, Poppema S. Primary breast lymphoma. An immunohistologic study of 20 new cases. Cancer 1990; 66 :2602-11.
- Giardini R, Piccolo C, Rilke F. Primary non-Hodgkin's lymphomas of the female breast. Cancer 1992; 69 :725-35.
- Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP. Lymphomas of the breast: primary and secondary involvement. Cancer 2002; 94:6-13.
- Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V. Primary breast lymphoma. Leuk Lymphoma 2003; 44:1173-8.
- Brogi E, Harris NL. Lymphomas of the breast: pathology and clinical behavior. Semin Oncol 1999; 26 :357-64.
- WongWW, Schild SE, HalyardMY, Schomberg PJ. Primary non- Hodgkin lymphoma of the breast: the Mayo clinic experience. J Surg Oncol 2002; 80:19-25.
- Giardini R, Piccolo C, Rilke F. Primary non-Hodgkin's lymphomas of the female breast. Cancer 1992; 69 :725-35.
- Abbondanzo SL, Seidman JD, Lefkowitz M, Tavassoli FA, Krishnan J. Primary diffuse large B-cell lymphoma of the breast. A clinicopathologic study of 31 cases. Pathol Res Pract 1996; 192: 37-43.
- F. Montilla,F. Grolier, D. Gholam, et al Primary breast lymphoma during pregnancy: A case report Gynecol Obstet & Fertil 2007;35: 1129-1132.