CENTRAL NERVOUS SYSTEM DYSGERMINOMA A CLINICOPATHOLOGICAL STUDY OF 3 CASES

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Vol. 87 No. 3 (2009): Issue Mar 2009

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Selma Bellil
Service d'Anatomie et de Cytologie Pathologiques. Hôpital la Rabta
Emna Braham
Service d'Anatomie et de Cytologie Pathologiques. Hôpital la Rabta
Faten Limaiem
Service d'anatomie pathologique Hôpital La Rabta Tunis.
Khadija Bellil
Service d'anatomie pathologique Hôpital La Rabta Tunis.
Ines Chelly
Service d'anatomie pathologique Hôpital La Rabta Tunis.
Amina Mekni
Department of Pathology
Slim Haouet
Department of Pathology
Moncef Zitouna
Service d'anatomie pathologique Hôpital La Rabta Tunis.
Hafedh Jemel
Service de Neurochirurgie. Institut national de Neurologie
Moncef Khaldi
Service de Neurochirurgie. Institut national de Neurologie
Nidhameddine Kchir
Service d'anatomie pathologique Hôpital La Rabta Tunis.

Abstract

Background: Intracranial germ cell tumors are rarely seen and typically localize in the pineal or suprasellar region. The largest category of germ cell tumors is dysgerminoma.
Aim: to describe clinicopathological features and immunohistochemical profile of dysgerminomas.
Case report: We report three cases of central nervous system dysgerminomas. There were two young women and a man who were 6, 11 and 23 year-old. They presented with symptoms of insipidus diabetes (n=3) with association to visual field defects in the third case. Radiological findings showed a supra seller lesion in two cases. Double localization in the pineal and suprasellar regions was seen in the third case. Histologic examination and immunohistochemical
study of surgical specimen were consistent with primary central nervous system dysgerminoma.

Keywords:

Dysgerminoma, histology, radiotherapy

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