ASSOCIATION BUDD CHIARI SYNDROME, ANTIPHOSPHOLIPID SYNDROME AND GRAVE'S DISEASE

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Vol. 87 No. 2 (2009): Issue Feb 2009

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Leila Mouelhi
Service de Gastro-entérologie. Hôpital Charles Nicolle. Tunis.
Mouna Chaieb
Radhouane Debbeche
Service de Gastro-entérologie. Hôpital Charles Nicolle. Tunis.
Mohamed Salem
Service de Gastro-entérologie. Hôpital Charles Nicolle. Tunis.
Imene Sfar
Laboratoire d'Immunologie. Hôpital Charles Nicolle. Tunis.
Sinda Trabelsi
Service de Gastro-entérologie. Hôpital Charles Nicolle. Tunis.
Yosr Gorgi
Laboratoire d'Immunologie. Hôpital Charles Nicolle. Tunis.
Taoufik Najjar
Service de Gastro-entérologie. Hôpital Charles Nicolle. Tunis.

Abstract

Background: Antiphospholipid syndrome is revealed by Budd Chiari syndrome in 5% of the cases. Antiphospholipid syndrome is characterized by venous or arterial thrombosis, foetal loss and positivity of antiphospholipid antibodies, namely lupus anticoagulant, anticardiolipin antibodies and anti-beta2-glycoprotein
I. Anticardiolipin antibodies was reported in auto-immune thyroid disorders, particularly in Grave's disease. Antiphospholipid syndrom associated to Grave's disease was reported in only three cases.
Aim: To describe a case report of association of Grave’s disease and antiphospholipid syndrome.
Observation: We report the first case of Grave's disease associated with antiphospholipid syndrome, revealed by Budd Chiari syndrome.
Conclusion: Our observation is particular by the fact that it is about a patient presenting a Grave’s disease associated with antiphospholipid syndrome revealed by Budd Chiari syndrome. This triple association has never been reported in literature. Although association between antiphospholipid syndrome and Grave’s disease was previously described, further studies evaluating the coexistence of these two affections in the same patient would be useful.

Keywords:

Anticardolipin, Antiphospholipid syndrome, Thrombosis, Grave's disease, Budd Chiari syndrome

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References

  1. Cooper DS. Hyperthryroidism. Lancet 2003;362:459-68.
  2. Uthman I, Salti I, Khamashta M. Endocrinologic manifestations of the antiphospholipid syndrome. Lupus 2006;15:485-9.
  3. De Carolis C, Greco E, Guarino MD, Perricone C et al. Anti-thyroid antibodies and antiphospholipid syndrome: Evidence of reduced fecundity and of poor pregnancy outcone in recurrent spontaneous aborters. Am J Reprod Immunol 2004;52:263-6.
  4. Asherson RA, Cervera R. Unusual manifestations of the antiphospholipid syndrome. Clin Rev Allergy Immunol 2003;25:61-78.
  5. Plessier A. Syndrome de Budd-Chiari. Gastroenterol Clin Biol 2006;30:1162-9.
  6. Miyakis S, Lockshin MD, Atsumi T et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306.
  7. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Engl J Med 2002;346:752-63.
  8. Takahashi A, Tamura A, Ishikawa O. Antiphospholipid antibody syndrome complicated by Grave's disease. J Dermatol 2002;29:776-80.
  9. Marongiu F, Conti M, Murtas ML. Anticardiolpin antibodies in Grave's disease: relationship with thrombin activity in vivo. Thromb Res 1991;64:745-9.
  10. Paggi A, Caccavo D, Ferri GM et al. Anti-cardiolipin antibodies in autoimmune thyroid diseases. Clin Endocrinol 1994;40:329-33.
  11. Nabriski D, Ellis M, Ness-Abramof R, Shapiro M, Shenkman L. Autoimmune thyroid disease and antiphospholipid antibodies. Am J Hematol 2000;64:73-5.
  12. Hofbauer LC, Spitzweg C, Heufelder AE. Graves' disease associated with the primary antiphospholipid syndrome. J Rheumatol 1996;23:1435-7.
  13. Mayaudon H, Crozes P, Riveline JP, Boyer B, Simon P, Bauduceau B. Anticorps antiphospholipides au cours d'une maladie de Basedow. Presse Med 1994;23:1496.