BONE LOSS OWING TO INFLAMMATORY BOWEL DISEASE: Prospective study about 50 cases

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Vol. 87 No. 2 (2009): Issue Feb 2009

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Kaouther Saadallaoui Ben Hamida
Internal Medicine Department Tunisia
Meriem Serghini
Department of Gastroenterology A
Iméne Ksontini
Service de Médecine Interne. Hôpital des Forces de sécurité Intérieure. 2070 La Marsa.
Hanéne Kedadi
Service de Médecine Interne. Hôpital des Forces de sécurité Intérieure. 2070 La Marsa.
Lamia Ben Yaghléne
Service de Médecine Interne. Hôpital des Forces de sécurité Intérieure. 2070 La Marsa.
Wassila Bougassas
Service de Médecine Interne. Hôpital des Forces de sécurité Intérieure. 2070 La Marsa.
Mohamed Hedi Dougui
Service de Médecine Interne. Hôpital des Forces de sécurité Intérieure. 2070 La Marsa.

Abstract

Aims: To evaluate the prevalence of osteoporosis during inflammatory bowel disease (IBD) and to determine the risk factors.
Methods: We conducted a prospective study that includes IBD patients. For all patients, bone mineral density was measured by dual-energy X-rays absorptiometry.
Results: Study has included 50 IBD patients; thirty had Crohn’s disease and 20 had ulcerative colitis. The average age of our patients was of 36,4 + 9,9 years. A low osseous mineral density was noted in 21 patients (45 %) distributed in 13 % of osteoporosis and 32 % of osteopenia. Only the age superior to 35 years, the duration of evolution of the disease superior to 10 years and intestinal resection constituted a risk factors of osteoporosis. After adaptation on the age and the intestinal resection the duration of evolution superior to 10 years persisted as risk factor of osteoporosis. The other risk factors: sex, type of IBD, denutrition and corticoids were not incriminated in the low osseous mineral density during IBD.
Conclusion: These results confirm the necessity of the systematic search of the osteoporosis during IBD with the aim of proposing an early and effective treatment.

Keywords:

Crohn's disease, ulcerative colitis, bone mineral density, osteoporosis

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References

  1. Kotzki P, MarchandiseX, Meunier P et al Intérêt et indications cliniques des mesures de masse osseuse par absorptiométrie biphotonique à rayon X. J Radiol 1994; 75:8-9.
  2. Roux C. Traitement médicamenteux des ostéoporoses postménopausiques et cortisoniques. Rev Rhum 2002; 69: 971-81.
  3. Abitbol V, Roux C, Chaussade S et al. Metabolic bone assessment in patients with inflammatory bowel disease. Gastroenterology 1995; 108: 417-422.
  4. Pollack R D, Karmeli F, Eliakim R et al . Femoral neck osteopenia in patients with in inflammatory bowel disease. Am J Gastroenterol 1998; 93: 1483- 1490.
  5. Silvennoinen J A, Karttunen TJ, Niemelä et al . A controlled study of bone mineral density in patients with inflammatory bowel disease. Gut 1995; 37:71-76.
  6. Bartram S, Peaston R, Rawlings D et al. Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease. World J Gastroenterol 2006 September 21; 12(35):5680-5686.
  7. Bjarnason I. Metabolic bone disease in patients with inflammatory bowel disease. Rheumatology 1999; 38:801.
  8. Bernstein CN, Blanchard JF, Leslie W et al. The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study. Ann. Intern Med 2000; 133: 795-9.
  9. Card T, West J, Hubbard R et al. Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use: a population based cohort study. Gut 2004; 53:251-5.
  10. Boubaker J, Feki M, Hsairi M, et al. Ostéoporose et maladies inflammatoires chroniques de l'intestin. Gastoenterol Clin Biol 2003; 27:901-907.
  11. Roux C, Abitbol V, Chaussade S et al. Bone loss in patients with inflammatory bowel disease: a prospective study. Osteoporos.Int 1995; 5: 156-60.
  12. Von Tirpitz C. Steder -Neukamm U. Glas K et al. Osteoporosis in inflammatory bowel disease- resultas of a survey among members of the German Crohn's and ulcerative colitis Association. Z Gastroenterol 2003; 41:1145-1150.
  13. Robinson R, Ai-Azzwi F, Iqbal SJ. Osteoporosis and determinants of bone density with Crohn's disease. Dig Dis Sci. 1998; 43: 2500 - 6.
  14. Vestergaard P, Krogh K ,Rejnmark L et al .Fractures risk is increased in Crohn's disease , but not in ulcerative colitis .Gut 2002;46:176-181.
  15. De Vos M, De Keyser F, Mielants H et al. Review article bone and joint disease in inflammatory bowel disease. Aliment Pharmacol Ther 1998; 12: 397-404.
  16. Roux C, Abiitbol V, Douggados M et al.L'ostéoporose des entérocolites inflammatoires. Hépato-Gastro 2000; 7:179-183.
  17. Frei P, Fried M, Hungerbuhler V et al. Analysis of risk factors for low bone mineral density in inflammatory bowel disease. Digestion 2006; 73: 40-46.
  18. Jahnsen J, Falch J A, Mowinckel P et al. Bone mineral density in patients with inflammatory bowel disease: A populationbased prospective two-year follow-up study. Scand J Gastroenterol 2004; 39:145-153.
  19. Sahli H, Meddeb N, Landolsi F et al. Ostéoporose et maladie de crohn . Rev Rhum 2005; 72:820-824.
  20. Valentine JF,Sninsky CA. Prevention and treatment of osteoporosis in patients with inflammatory bowel disease. Am J Gastroentrol 1999; 94: 878-83.
  21. Andreassen H, Hylander E, Rix M. Gender, age,and body weigt are major factors for bone mineral density in crohn's disease: a case-control cross-sectional study of 113 patients. Am J Gastroenterol 1999; 94: 824-8.
  22. Vogelsang H , Ferenci P, Resch H et al. Prevention of bone mineral loss in patients with Crohn's disease by long-term oral vitamin D supplementaton. Eur J Gastroenterol Hepatol 1995; 7: 609-14.