CLINICOPATHOLOGICAL CHARACTERISTICS OF SYNCHRONOUS BILATERAL BREAST CARCINOMAS, CASE SERIES OF 30 PATIENTS

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Vol. 86 No. 2 (2008): Issue Feb 2008

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Jamel Ben Hassouna
Department of surgical oncology
Tarak Damak
Department of surgical oncology.
Riadh Chargui
Department of surgical oncology.
Maher Slimene
Department of surgical oncology.
Amine chkir
Department of surgical oncology.
Mohamed Ali Ayadi
Department of surgical oncology.
Mohamed Mtallah
Department of surgical oncology.
Monia Hechiche
Department of surgical oncology.
Amor Gamoudi
Department of pathology
Fethi Khomsi
Department of surgical oncology.
Tarak Ben Dhiab
Department of surgical oncology.
Khaled Rahal
Department of surgical oncology.

Abstract

Aim : The objective of this study is to determine the clinicopathologic characteristics; incidence and prognosis value of synchronous bilateral breast carcinoma (SBBC).
Methods : This is a retrospective study done in Salah Azaiz Institute of Tunis about 30 patients with synchronousbilateral breast carcinomas diagnosed and treated over a 21- years period going from 1977 to 1997. The definition of synchronous breast lesions is the developpement of the contralateral breast cancer within 6 months.
Results : Median age was 49 years. The incidence of SBBC was 0.52%. History family was noted in 3% of our population. Mean tumor size was 40 mm (15-145). Breast conserving therapy was done in 16% of cases (9 patients). Five-year overall survival was 40%. Five year survival rates were 72 and 17% for stage II and III, respectively. Main prognostic factors for survival were lymph node involvement (P=0.004) and disease stage (P=0.02).
Conclusion : Synchronous bilateral breast carcinoma is a rare entity, with a problem of definition concerning the delay of bilaterlisation. Their prognosis is similar to that of unilateral breast carcinoma patients of equal stage. Hence, breast conserving therapy can be used s fely if indicated.

Keywords:

Synchronous breast carcinoma, epidemiology, diagnosis, treatment, prognosis

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