La tunisie Medicale - 2022 ; Vol 100 ( n°08 ) : 626-641
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Résumé

Introduction: Bien que les lésions pulmonaires soient parmi les principales causes de décès par Polyarthrite Rhumatoïde (PR), peu d’études ont évalué les données spirométriques et pléthysmographiques et le profil des patients atteints de PR, en particulier ceux avec des Anticorps Anti-Peptides Citrullinés Positifs (AAPC+).
Objectif: Comparer les données spirométriques et pléthysmographiques et le profil des patients PR AAPC+ et AAPC-.
Méthodes: Cette étude pilote comparative a été réalisée sur une période de deux ans (2018-2019) à Alger (Algérie). Elle a inclus deux groupes de patients nonfumeurs ayant une PR: 26 AAPC+ et 33 AAPC-. La PR a été diagnostiquée selon les critères de classification internationale (ACR/EULAR-2010). Une spirométrie et une pléthysmographie ont été réalisées. Les définitions suivantes ont été appliquées: Déficit Ventilatoire Obstructif (DVO): z-score du VEMS/CVF <-1,645; Déficit Ventilatoire Restrictif (DVR): z-score de la Capacité Pulmonaire Totale (CPT) <-1,645; Déficit Ventilatoire Mixte (DVM): z-score du VEMS/CVF <-1,645 et z-score de la CPT <-1,645; distension pulmonaire: z-score du volume résiduel >+1,645; Déficit Ventilatoire Non-spécifique (DVNS): z-score du VEMS <-1,645, z- score de la CVF <-1,645, z-score du VEMS/CVF ≥ -1,645 et z-score de la CPT ≥ -1,645.
Résultats: Le groupe AAPC- était plus âgé que le groupe AAPC+ d’environ 10 ans (63±13 contre 53±12 ans, p=0,0025 ; respectivement). Les groupes AAPC+ et AAPC- incluaient des pourcentages similaires de patients ayant un DVR, un DVM, et un DVNS (23,1 contre 45,5%, p=0,0745; 3,8 contre 3,0%, p=0,8654; et 7,7 contre 6,1%, p=0,8086; respectivement). Comparé au groupe AAPC-, le groupe AAPC+ incluait un pourcentage plus élevé de patients ayant une DVO et une distension pulmonaire (9,1 contre 38,5%, p=0,0069; 9,1 contre 42,3%, p=0,0029; respectivement).
Conclusion. Comparé au groupe AAPC-, le groupe AAPC+ incluait plus patients ayant une distension pulmonaire et/ou un DVO, et des pourcentages similaires de DVR, DVM et DVNS.

Mots Clés
Article
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