La tunisie Medicale - 2022 ; Vol 100 ( n°04 ) : 285-294
[ 218 times seen ]
Summary

Background : The MTHFR gene polymorphisms are closely related to the chronic myeloid leukemia (CML). Case-control studies have associated the MTHFR polymorphisms and susceptibility to CML but the results were not conclusive.
Aim : To assess this association through an update meta-analysis.
Methods : A descriptive and qualitative study was conducted among students in the 6th year of the faculty during the academic year 2020/2021. The data were collected through a questionnaire written in french evaluating the teaching methods. A focus group of ten persons was led to understand better student’s opinions.
Results : Totally, 17 and 12 case-control studies including CML cases and controls were enrolled in the meta-analysis respectively for C677T and A1298C polymorphism and CML risk. A poor association between the C677T (T vs C ; OR= 1,28; IC95%= [1,01;1,63]; p=0,04) and the one not significant between the A1298C (C vs A ; OR= 1,52; IC95%= [0,92; 2,51]; p= 0,1) polymorphisms and the CML risk for overall population were found.
Conclusion : The results of this meta-analysis suggested no significant association between C677T and A1298C polymorphisms and CML risk leading to consider other factors such us folic acid intake, gene-gene and gene- environment interactions.

Key - Words
Article
Login
E-mail :
Password :
Remember Me Forgot password? Sign UP
Archives
2022
January
February
March
April
May
June
July
August
September
October
November
December
Keywords most used
Tunisia treatment Child surgery diagnosis prognosis Children Crohn’s disease epidemiology Risk factors Breast cancer screening Cancer obesity prevalence
Newsletter
Sign up to receive our newsletter
E-mail :
Stay in Touch
Join Us! !