La tunisie Medicale - 2019 ; Vol 97 ( n°012 ) : 1399-1406
[ 2512 times seen ]
Summary

Introduction: Renal involvement is a common and serious manifestation of systemic lupus erythematosus (SLE) and it is life-threatening.
Aim: To identify the predictive factors of the lupus nephritis (LN).
Methods:
A descriptive, analytical, single-centre, retrospective study of 115 patients with SLE (ACR 1997) was carried out in an internal medicine department for a period of 20 years from 1997 until 2017. LN was diagnosed by proteinuria ≥ 0.5 g /24h and / or urine sediment abnormality. Eighty patients did not have kidney damage during the follow-up and thirty-five developed renal involvement after SLE diagnosis
Results:
The univariate analysis retained several epidemiological, clinical and biological correlation parameters, according to the development of lupus nephritis, statistically significant. They are as follows, the male gender, the age of diagnosis of SLE less than or equal to 34 years, the presence of malar rash by the time of SLE diagnosis, naso/pharyngeal ulcerations, leucopoenia, positivity of anti-Sm antibody and low C3 complement.
The multivariate analysis had found that age less than or equal to 34 years at the diagnosis of the SLE was the only predictive factor of the onset of LN (OR=5.1 and HR=3.4).
Conclusion:
Given the seriousness of the pathology and the complexity of its management, LN should be detected as soon as possible and must be treated appropriately by selecting the lupus population at risk for developing a serious LN.

Key - Words
Article
Login
E-mail :
Password :
Remember Me Forgot password? Sign UP
Archives
2020
January
February
March
April
May
June
July
August
September
October
November
December
Keywords most used
Child treatment diagnosis surgery prognosis Tunisia Children Crohn’s disease Breast cancer Cancer screening epidemiology Ulcerative colitis prevention Risk factors
Newsletter
Sign up to receive our newsletter
E-mail :
Stay in Touch
Join Us! !